Research Article

Anti-PD-1/PD-L1 Antibody Therapy for Pretreated Advanced or Metastatic Nonsmall Cell Lung Carcinomas and the Correlation between PD-L1 Expression and Treatment Effectiveness: An Update Meta-Analysis of Randomized Clinical Trials

Table 2

Baseline characteristics of RCTs included in the analysis.

StudyYearStudy typeInterventionTreatment regimensNo. of patients

Brahmer2015Phase IIINivolumab
3mg/kg ivgtt q2w
135
Docetaxel75mg/m2 ivgtt q3w137
Borghaei2015Phase IIINivolumab
3mg/kg ivgtt q2w
292
Docetaxel75mg/m2 ivgtt q3w290
Pembrolizumab
2mg/kg ivgtt q3w
344
Herbst2015Phase IIIPembrolizumab
10mg/kg ivgtt q3w
346
Docetaxel75mg/m2 ivgtt q3w343
Fehrenbacher2016Phase IIAtezolizumab
1200mg ivgtt q3w
144
Docetaxel75mg/m2 ivgtt q3w143
Rittmeyer2017Phase IIIAtezolizumab
1200mg ivgtt q3w
425
Docetaxel75mg/m2 ivgtt q3w425