Research Article
A Genomewide Integrative Analysis of GWAS and eQTLs Data Identifies Multiple Genes and Gene Sets Associated with Obesity
Table 1
List of significant genes identified by SMR.
| | | Gene | Top SNP | MAF | GWAS | SMR | | β | value | β | value |
| | BMI | TUFM | rs2008514 | 0.386 | | 1.46 × 10−23 | | 3.16 × 10−22 | | SPI1 | rs11039212 | 0.670 | | 8.75 × 10−13 | | 2.83 × 10−12 | | APOB48R | rs1968752 | 0.359 | | 4.69 × 10−17 | | 4.13 × 10−12 | | MYBPC3 | rs11039212 | 0.670 | | 8.75 × 10−13 | | 4.60 × 10−12 | | SPNS1 | rs8045689 | 0.295 | | 1.17 × 10−10 | | 1.52 × 10−10 | | MAP2K5 | rs4331293 | 0.258 | | 2.24 × 10−13 | | 1.92 × 10−10 | | FNBP4 | rs10838774 | 0.458 | | 6.73 × 10−13 | | 2.51 × 10−8 | | NT5C2 | rs11191580 | 0.092 | | 2.59 × 10−9 | | 2.62 × 10−8 | | HS.371060 | rs4704221 | 0.391 | | 1.56 × 10−8 | | 3.08 × 10−8 | | GTF3A | rs7988412 | 0.187 | | 1.23 × 10−8 | | 4.02 × 10−8 | | SBK1 | rs4788076 | 0.354 | | 2.16 × 10−17 | | 1.89 × 10−7 | | C18ORF8 | rs1788821 | 0.338 | | 1.89 × 10−8 | | 2.48 × 10−7 | | C5ORF37 | rs17649266 | 0.210 | | 2.70 × 10−8 | | 4.28 × 10−7 | | NPC1 | rs1624695 | 0.329 | | 2.21 × 10−8 | | 1.66 × 10−6 | | ADCY3 | rs6737082 | 0.462 | | 2.10 × 10−16 | | 1.80 × 10−6 | | ARL3 | rs12415043 | 0.095 | | 4.07 × 10−7 | | 1.97 × 10−6 | | L3MBTL3 | rs6569648 | 0.228 | | 1.84 × 10−6 | | 2.30 × 10−6 | | SAE1 | rs8101149 | 0.280 | | 7.75 × 10−10 | | 2.46 × 10−6 | | CUGBP1 | rs12419692 | 0.363 | | 1.56 × 10−14 | | 4.05 × 10−6 | | ZNF668 | rs11150604 | 0.377 | | 4.34 × 10−6 | | 7.29 × 10−6 |
| | WHR | CPEB4 | rs966544 | 0.314 | | 2.3 × 10−12 | | 5.48 × 10−12 | | WARS2 | rs10923698 | 0.142 | | 4.0 × 10−9 | | 2.21 × 10−8 | | L3MBTL3 | rs6569648 | 0.228 | | 3.6 × 10−6 | | 9.06 × 10−6 |
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