In Vivo Study on Analgesic, Muscle-Relaxant, Sedative Activity of Extracts of Hypochaeris radicata and In Silico Evaluation of Certain Compounds Present in This Species

Table 5

Analgesic potential of crude extract and its fractions of H. radicata. Values represent the number of writhing, 30 minutes after treatment with distilled water (10 ml/kg, control), crude methanolic extract, and its various fractions (25, 50, and 100 mg/Kg), or diclofenac (10 mg/kg). Data presented as mean ± SEM (). , , , all compared with control.

Treatment	Dose	No. of writhing ± SEM
Normal saline	10 ml/kg	65 ± 3.46
Diclofenac sodium	10 mg/kg	17.6 ± 1.14
Crude extract	25 mg/kg	52 ± 2.44
	50 mg/kg	33 ± 1.10
	100 mg/kg	17 ± 0.87
n-Hexane fraction	25 mg/kg	53 ± 2.11
	50 mg/kg	49 ± 1.77
	100 mg/kg	45 ± 0.48
Chloroform fraction	25 mg/kg	50 ± 1.44
	50 mg/kg	29.67 ± 0.76
	100 mg/kg	14 ± 0.66
Ethyl acetate fraction	25 mg/kg	48.23 ± 0.68
	50 mg/kg	26. ± 0.88
	100 mg/kg	12.50 ± 67