In Vivo Study on Analgesic, Muscle-Relaxant, Sedative Activity of Extracts of Hypochaeris radicata and In Silico Evaluation of Certain Compounds Present in This Species

Table 6

Muscle relaxant activity of crude extract and its fractions of Hypochaeris radicata. The values are presented as percentage ± SEM for each animal ().

Groups	Dose (mg/kg)	Inclined plan test (%)			Traction test (%)
		30 min	60 min	90 min	30 min	60 min	90 min
Distilled water	10 ml	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00	0 ± 0.00
Diazepam	1	100 ± 0.00	100 ± 0.00	100 ± 0.00	100 ± 0.00	100 ± 0.00	100 ± 0.00
Crude extract	25	1.44 ± 0.56	2.55 ± 0.77	3.21 ± 0.55	1.48 ± 0.56	2.53 ± 0.64	4.31 ± 0.50
	50	1.87 ± 0.57	4.18 ± 0.69	4.20 ± 1.00	1.84 ± 0.60	3.56 ± 0.69	5.10 ± 0.70
	100	3.50 ± 0.58	4.97 ± 0.88	7.00 ± 1.18	3.65 ± 0.63	4.70 ± 0.60	7.01 ± 1.14
n-Hexane fraction	25	1.25 ± 0.50	3.00 ± 0.55	3.24 ± 0.66	1.30 ± 0.56	3.25 ± 0.55	3.78 ± 0.60
	50	2.57 ± 0.70	4.10 ± 0.97	4.33 ± 0.88	2.68 ± 0.73	4.27 ± 0.95	4.76 ± 0.99
	100	4.30 ± 0.59	4.12 ± 0.77	6.00 ± 1.00	4.05 ± 0.59	4.25 ± 0.70	6.63 ± 1.00
Chloroform fraction	25	1.66 ± 0.52	2.77 ± 0.78	3.82 ± 0.66	1.68 ± 0.87	2.66 ± 0.66	4.55 ± 0.52
	50	1.95 ± 0.65	4.88 ± 0.80	4.50 ± 0.60	2.04 ± 0.84	3.80 ± .87	5.44 ± 0.60
	100	3.66 ± 0.78	5.20 ± 0.59	7.60 ± 0.90	3.90 ± 0.60	4.97 ± 0.80	7.50 ± 1.10
Ethyl acetate fraction	25	1.88 ± 0.60	2.90 ± 0.63	3.98 ± 0.68	2.00 ± 0.88	3.01 ± 0.60	5.50 ± 0.63
	50	2.20 ± 0.63	3.30 ± 0.60	4.50 ± 0.77	2.98 ± 0.76	4.15 ± 0.65	6.45 ± 0.60
	100	4.63 ± 0.70	5.20 ± 0.77	6.00 ± 0.88	4.40 ± 0.64	5.98 ± 0.65	7.80 ± 0.80