In Vivo Study on Analgesic, Muscle-Relaxant, Sedative Activity of Extracts of Hypochaeris radicata and In Silico Evaluation of Certain Compounds Present in This Species

Table 7

Sedative activity of crude extract and its fractions of H. radicata. Values represent the number of lines crossed by an animal in a box, 30 minutes after treatment with distilled water (10 ml/kg, control), crude methanolic extract, and its various fractions (25, 50, and 100 mg/Kg), or diazepam (0.5 mg/kg). Data presented as mean ± SEM (). , , , all compared with control.

Sample	Dose	No. of lines crossed/10 min
Distilled water	10 ml/Kg	126 ± 1.25
Diazepam	0.5 mg	6 ± 0.13
Crude extract	25 mg/kg	108.25 ± 5.01
	50 mg/kg	100.24 ± 4.22
	100 mg/kg	92.45 ± 4.00
n-Hexane fraction	25 mg/kg	119.48 ± 5.80
	50 mg/kg	112.44 ± 4.87
	100 mg/kg	104.25 ± 4.35
Chloroform fraction	25 mg/kg	112.35 ± 3.88
	50 mg/kg	107.85 ± 2.33
	100 mg/kg	102.39 ± 1.00
Ethyl acetate fraction	25 mg/kg	92.35 ± 1.77
	50 mg/kg	86.88 ± 1.33
	100 mg/kg	80.41 ± 1.00