Reducing Blood Loss in Revision Total Hip and Knee Arthroplasty: Tranexamic Acid Is Effective in Aseptic Revisions and in Second-Stage Reimplantations for Periprosthetic Infection
Table 3
Main outcome variables. Given are the mean values (SD), in addition to minimum, maximum, and median for surgical time.
Outcome variables
TXA Revision THA n=96 Revision TKA n=51
No TXA Revision THA n=103 Revision TKA n=52
p-value
Revision THA
Surgical time [min]
152.6 (51.6)
150.0 (63.7)
0.7500
Min; Max; Median
50; 290; 150
60; 420; 130
Ht POD 5
0.288 (0.029)
0.278 (0.029)
0.0300
INR postop.
1.09 (0.07)
1.08 (0.07)
0.4700
RBC postop. [unit]
1.00 (1.11)
1.41 (1.49)
0.0280†
RBC transfused total [unit]
1.49 (1.62)
2.01 (1.92)
0.0400
Transfusion rate
0.57 (0.50)
0.65 (0.48)
0.2600†
Calc. blood loss [ml]
2916 (1226)
3611 (1474)
0.0004
DVT/PE
0/0
0/1
-/0.3500
Complication rate
0.21 (0.41)
0.15 (0.36)
0.2700†
Revision TKA
Surgical time [min]
175.1 (43.5)
174.0 (53.5)
0.9100
Min; Max; Median
105; 300; 165
120; 360; 163
Ht POD 5
0.279 (0.037)
0.274 (0.025)
0.3800†
INR postop.
1.09 (0.07)
1.11 (0.09)
0.2200
RBC postop [unit]
0.78 (1.15)
1.13 (1.37)
0.1600
RBC transfused total [unit]
1.18 (1.57)
1.54 (1.66)
0.2600
Transfusion rate
0.47 (0.50)
0.58 (0.50)
0.2900
Calc. blood loss [ml]
2756 (975)
3441 (1100)
0.0012
DVT/PE
0/0
0/0
-/-
Complication rate
0.23 (0.43)
0.29 (0.46)
0.5300
TXA, tranexamic acid; THA, total hip arthroplasty; TKA, total knee arthroplasty; POD, postoperative day; Ht, hematocrit; INR, international normalized ratio; RBC, packed red blood cells; DVT, deep vein thrombosis; PE, pulmonal embolism; : significant; †: Welch’s test.
