Salivary proteins identified in WS of SSc patients according to Giusti et al. [14].
Proteins
Swiss-Prot/NCBI
Function
Calgranulin A
P05109
Present in chronic inflammation and in epithelial cells constitutively or induced during dermatoses. Involved in the metabolism of arachidonic acid in human neutrophils. Seem to have a major role in inflammatory and immunological responses. May interact with components of the intermediate filaments in monocytes and epithelial cells. May play a role in inhibiting the matrix metalloproteinases activity.
Calgranulin B
P06702
Present in acute and in chronic inflammation. Stimulate neutrophil adhesion. Involved in the metabolism of arachidonic acid in human neutrophils. May play a role in inhibiting the protein kinases and the matrix metalloproteinases activity. May interact with components of the intermediate filaments in monocytes and epithelial cells.
Cystatin B
P04080
Proteinase inhibiting properties. Tightly binding reversible inhibitor of cathepsins L, H, and B.
Psoriasin
P31151
Present in fetal ear, skin, and tongue and human cell lines. Highly expressed in psoriasis and in other inflammatory skin diseases. Seem to participate in tumor progression. Also highly expressed in the urine of patients with bladder squamous cell carcinoma.
ß2-Microglobulin
Q6IAT8
Component of the MHC class I molecules.
Cyclophilin A
P62937
Involved in expression, folding, and degradation of proteins. Catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Glyceraldeyde-3 P-dehydrogenase
P04406
Glycolytic enzymes present in the cytoplasm. Play a role in degradation of carbohydrate and glycolysis.
Triose phosphate isomerase
P60174
A highly conserved glycolytic enzyme. Mediated by glycolysis in red blood cells and in brain cells. Biosynthesis of carbohydrate and gluconeogenesis.
Actin-related protein 2/3 complex subunit 2
O15144
Strong candidate for the control of actin polymerization in chemotaxis.
