Research Article
Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients
Table 1
Comparison of the baseline characteristics of nondiabetic hemodialysis patients with and without nonalcoholic fatty liver disease (NAFLD).
| | | Non-NAFLD | NAFLD | P value | | N=52 (73%) | N=19 (27%) |
| | Age (years) | 56.4 | (12.0) | 55.0 | (10.9) | 0.656 | | Male (%) | 44% | | 32% | | 0.337 | | BMI | 21.7 | (3.8) | 20.4 | (2.7) | 0.164 | | Hemodialysis vintage (months) | 85.6 | (65.0) | 93.9 | (65.0) | 0.630 | | Dialysis membrane (Cellulose %) | 38% | | 58% | | 0.144 | | Hepatitis B | 3 | | 1 | | 0.907 | | Hepatitis C | 7 | | 1 | | 0.340 |
| | Adequacy of hemodialysis | | | | | | | Kt/V | 1.51 | (0.24) | 1.54 | (0.29) | 0.640 | | URR | 0.77 | (0.05) | 0.78 | (0.07) | 0.756 |
| | Hemogram | | | | | | | Hemoglobin (g/dL) | 10.5 | (1.1) | 10.5 | (0.9) | 0.796 | | Platelet (1000/uL) | 194 | (41) | 201 | (41) | 0.531 |
| | Biochemistry | | | | | | | Sugar (mg/dL) | 128 | (37) | 145 | (62) | 0.175 | | Calcium (mg/dL) | 9.1 | (0.8) | 9.1 | (0.9) | 0.918 | | Phosphorus (mg/dL) | 4.9 | (1.3) | 4.7 | (1.2) | 0.402 | | Intact parathyroid hormone (ug/L) | 402 | (371) | 277 | (328) | 0.203 | | Albumin (g/dL) | 3.72 | (0.30) | 3.77 | (0.34) | 0.513 | | Blood urea nitrogen (mg/dL) | 65 | (15) | 68 | (13) | 0.514 | | Creatinine (mg/dL) | 11.6 | (2.4) | 10.9 | (1.6) | 0.240 | | Ferritin (ng/mL) | 395 | (216) | 398 | (244) | 0.959 |
| | Liver function | | | | | | | AST (U/L) | 20 | (9) | 19 | (7) | 0.658 | | ALT (U/L) | 16 | (9) | 14 | (6) | 0.329 | | Total bilirubin (mg/dL) | 0.33 | (0.13) | 0.29 | (0.08) | 0.151 | | Alkaline phosphatase (IU/L) | 104 | (45) | 93 | (68) | 0.433 |
| | Lipid profile | | | | | | | Triglycerides (mg/dL) | 156 | (86) | 174 | (96) | 0.451 | | Cholesterol (mg/dL) | 185 | (33) | 194 | (42) | 0.342 | | Low-density lipoprotein (mg/dL) | 109 | (27) | 108 | (36) | 0.961 | | High-density lipoprotein (mg/dL) | 45 | (9) | 49 | (15) | 0.150 |
| | Dialysis related medications | | | | | | | Vitamin C supplement | 6% | | 0% | | 0.285 | | Intravenous iron supplement | 29% | | 0% | | 0.008 | | Activated vitamin D3 supplement | 21% | | 21% | | 0.993 |
| | Oxidative stress biomarkers and mitochondrial function | | | | | | | TBARS (uM/L) | 0.69 | (0.38) | 0.80 | (0.36) | 0.311 | | Thiol (uM/L) | 1.74 | (0.40) | 1.56 | (0.41) | 0.111 | | GPx (U/L) | 206.19 | (44.66) | 233.05 | (49.55) | 0.033 | | SOD (U/L) | 394.71 | (161.38) | 455.27 | (180.54) | 0.179 | | MtDNA copy number | 277.30 | (183.40) | 439.25 | (267.34) | 0.006 |
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Values are expressed as mean (SD) or number (%). .Abbreviations. SD, standard deviation; NAFLD, nonalcoholic fatty liver disease; URR, urea reduction ratio; AST, Aspartate Aminotransferase; ALT, alanine aminotransferase; BMI, body mass index; TBARS, thiobarbituric acid reactive substances; GPx, glutathione peroxidase; SOD, superoxide dismutase; MtDNA, mitochondrial DNA. |
