Early Graft Loss after Kidney Transplantation: Endothelial Dysfunction of Renal Microvasculature

Figure 4

Ultrastructure of preimplantation kidney biopsy from deceased donor exposed to Takotsubo cardiomyopathy (TCM). (a) Glomerular endothelial cells are swollen, disintegrated, and partly detached from glomerular basement membrane. Swollen endothelial cell and extracellular debris fill the lumen of glomerular capillary. (b) Swollen endothelial cell in peritubular capillary. Their cytoplasmic membrane forms endothelial projections (microvilli). (c) Tubular epithelial cells are preserved but attenuated. Desmosomes are clearly seen. Apical brush border is thinner. (d) Arteriole with swollen and partly detached endothelial cells.

(a)

(b)

(c)

(d)