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BioMed Research International
Volume 2018 (2018), Article ID 4154185, 29 pages
Review Article

Polyphenols in Colorectal Cancer: Current State of Knowledge including Clinical Trials and Molecular Mechanism of Action

Discipline of Biomedical Sciences, Sydney Medical School, The University of Sydney, Cumberland Campus C42, East Street, Lidcombe, NSW 1825, Australia

Correspondence should be addressed to Fazlul Huq

Received 1 August 2017; Revised 8 November 2017; Accepted 17 December 2017; Published 15 January 2018

Academic Editor: Michael Linnebacher

Copyright © 2018 Md Nur Alam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Polyphenols have been reported to have wide spectrum of biological activities including major impact on initiation, promotion, and progression of cancer by modulating different signalling pathways. Colorectal cancer is the second most major cause of mortality and morbidity among females and the third among males. The objective of this review is to describe the activity of a variety of polyphenols in colorectal cancer in clinical trials, preclinical studies, and primary research. The molecular mechanisms of major polyphenols related to their beneficial effects on colorectal cancer are also addressed. Synthetic modifications and other future directions towards exploiting of natural polyphenols against colorectal cancer are discussed in the last section.