Candidate Biomarkers and Molecular Mechanism Investigation for Glioblastoma Multiforme Utilizing WGCNA

Table 1

The results for GO-BP function and KEGG pathway enrichment analysis (top 3 in each module are listed).

Module	GO-BP terms	PFDR	KEGG terms
Turquoise	GO:0007268~chemical synaptic transmission	6.65E-29	hsa04723: Retrograde endocannabinoid signaling	2.49E-14
	GO:0007269~neurotransmitter secretion	7.27E-15	hsa04727: GABAergic synapse	1.76E-10
	GO:0014047~glutamate secretion	7.47E-12	hsa05032: Morphine addiction	9.20E-10
Blue	GO:0051301~cell division	9.80E-40	hsa04110: Cell cycle	8.98E-15
	GO:0007067~mitotic nuclear division	8.74E-27	hsa03030: DNA replication	7.01E-05
	GO:0007062~sister chromatid cohesion	5.35E-22	hsa04114: Oocyte meiosis	1.74E-03
Brown	GO:0006954~inflammatory response	2.05E-04	hsa05133: Pertussis	5.25E-02
	GO:0030198~extracellular matrix organization	3.03E-03	hsa04064: NF-kappa B signaling pathway	1.21E-01
	GO:0051607~defense response to virus	4.84E-02	hsa04610: Complement and coagulation cascades	3.76E-01
Yellow	GO:0007417~central nervous system development	1.30E+01	hsa00340: Histidine metabolism	4.21E-01
	GO:0006915~apoptotic process	3.94E+01	hsa00410: beta-Alanine metabolism	3.06E+01
	GO:0055085~transmembrane transport	4.13E+01	hsa00330: Arginine and proline metabolism	4.45E+01

Notes: GO, gene-ontology; BP, biological process; KEGG, Kyoto Encyclopedia of Genes and Genomes; FDR, false discovery rate.