|
| Non-cell autonomous overgrowth/tumorigenesis |
| 1st mutation/mechanism | 2nd mutation/mechanism | Phenotype/references |
|
| hid/rpr overexpression | p35 expression (blocks effector caspase activity) generates “undead cells” | Eye-antennal or wing epithelial tissue non-cell autonomous overgrowth [59, 129–134] |
| Initiator caspase (Dronc) activation | Dependent on ROS production, JNK activation, Dpp, Wg upregulation/secretion |
|
| ptc mutant | ark (apaf1) mutant | Eye-antennal and wing epithelial tissue non-cell autonomous overgrowth [135] |
Hh pathway upregulation
| Results in upregulation of Dpp secretion from mutant cells and elevated Dpp signalling and Yki activity in the wild-type cells |
|
| RafGOF overexpression | Strong activation of JNK (hepACT) | Non-cell autonomous overgrowth and morphology changes of eye-antennal epithelial tissue [136] |
|
| Rac1 overexpression | Abrupt (BTB-POZ Zn finger transcription factor) | Eye-antennal epithelial tissue non-cell autonomous overgrowth [78] |
|
| Intertumoural cooperation |
|
RasV12 overexpression
| scrib mutant cells next to RasV12 overexpressing cells | Invasive neoplastic tumours of the larval eye neural-epithelium [137] |
| Activation of JNK and Upd upregulation and Jak-Stat signalling |
|
| | Mitochondrial dysfunction in RasV12 overexpressing cells next to RasV12 overexpressing cells | Invasive neoplastic tumours of the larval eye neural-epithelium [138, 139] |
| Results in ROS production, upregulation of JNK, deregulation of Hippo, secretion of Wg and Upd |
|
| Chromosome instability | Cell death blockage (p35 expression) | Invasive tumours in the wing epithelium [61, 140] |
Induced by spindle assembly or spindle-assembly checkpoint mutants leading to cell delamination (rod, bub3, asp)
| Results in Metabolic stress, ROS induced-JNK activation in epithelial cells promoting cell delamination |
| Results in Secretion of Wg, Upd from delaminated cells, promoting the proliferation of epithelial tumour cells |
|
| Spindle orientation defects | Cell death blockage (p35 expression) with mud knockdown | Invasive tumours in the eye-antennal or wing epithelium [61, 141, 142] |
Due to mutants/knockdown of genes involved in spindle alignment (mud, scrib, dlg) leading to cell delamination
| RasV12 or p35 expression with scrib or dlg |
| Results in Rho1-Wnd induced JNK activation in epithelial cells promoting cell delamination |
| Results in secretion of Wg, Upd from delaminated cells, promoting the proliferation of epithelial tumour cells |
|
| Dosage compensation mechanism mutants | p35 overexpression or deletion of rpr, hid, grim to block cell death | Invasive tumours in the wing epithelium [142] |
| Knockdown of msl1 or msl2 in males or Sxl in females | Results in ROS induced-JNK activation |
| Results in MMP1 expression in delaminating cells |
|
