Research Article

Derivation and Validation of the Potential Core Genes in Pancreatic Cancer for Tumor-Stroma Crosstalk

Table 2

Gene ontology functional enrichment analysis for 221 DEGs.

TermGO IDCountFold EnrichmentP value

GO biological process
positive regulation of transcription from RNA polymerase II promoterGO:0045944272.5117670522.34E-05
antigen processing and presentation of peptide antigen via MHC class IGO:0002474515.210144933.00E-04
mitophagyGO:0000422513.037267085.49E-04
negative regulation of transcription from RNA polymerase II promoterGO:0000122192.4082729479.04E-04
negative regulation of transcription, DNA-templatedGO:0045892152.7433127121.16E-03
transcription from RNA polymerase II promoterGO:0006366152.6684464791.51E-03
response to cAMPGO:005159159.9196597351.56E-03
cellular response to calcium ionGO:007127758.9471440752.29E-03
response to cytokineGO:003409758.7750836122.46E-03
apoptotic processGO:0006915152.4143087193.75E-03
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independentGO:0002480330.420289864.04E-03
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:1900740412.168115944.16E-03
positive regulation of transcription, DNA-templatedGO:0045893142.4808780084.30E-03
cell cycle arrestGO:000705074.5306814684.50E-03
positive regulation of apoptotic processGO:0043065103.0420289865.72E-03
regulation of cell deathGO:0010941324.889328066.09E-03
interferon-gamma-mediated signaling pathwayGO:006033356.42682187.52E-03
positive regulation of cell differentiationGO:004559749.8660399537.54E-03
cellular response to DNA damage stimulusGO:000697483.5100334457.87E-03
macroautophagyGO:001623656.0040045779.52E-03
cellular component
focal adhesionGO:0005925133.1232631119.71E-04
endoplasmic reticulumGO:0005783202.2690373031.30E-03
Golgi apparatusGO:0005794202.1770137742.08E-03
ER to Golgi transport vesicle membraneGO:001250759.0325138782.22E-03
cytosolGO:0005829521.4735395192.81E-03
integral component of lumenal side of endoplasmic reticulum membraneGO:0071556412.956985423.49E-03
PML bodyGO:001660565.7513149593.88E-03
melanosomeGO:004247065.5804838224.41E-03
membraneGO:0016020371.5798687915.09E-03
MHC class I protein complexGO:0042612325.619493915.76E-03
molecular function
transcription factor activity, sequence-specific DNA bindingGO:0003700252.3997372961.06E-04
transcription factor bindingGO:0008134123.8977141542.65E-04
protein bindingGO:00055151191.2495460783.06E-04
enzyme bindingGO:0019899123.3241766369.98E-04
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingGO:0001077103.9087246461.07E-03
chaperone bindingGO:005108766.8330297511.82E-03
DNA bindingGO:0003677321.7633625161.94E-03
RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:0000978112.8583237135.22E-03
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingGO:000370556.9883258825.60E-03
transcriptional repressor activity, RNA polymerase II transcription factor bindingGO:0001191323.061475417.11E-03
identical protein bindingGO:0042802172.0936987027.18E-03
RNA polymerase II activating transcription factor bindingGO:000110249.7100949097.88E-03
transcription regulatory region DNA bindingGO:004421283.4646348038.42E-03
neurexin family protein bindingGO:0042043319.766978929.66E-03