Harmful Roles of TLR3 and TLR9 in Cardiac Dysfunction Developing during Polymicrobial Sepsis

Figure 6

Lactate dehydrogenase (LDH) release from rat cardiomyocytes after in vitro exposure to purified histones (50 μg/ml) for 3 hr. at 37°C (left panel). Morphological evidence of damage to rat cardiomyocytes (bleb formation) after the exposure to the purified histones (50 μg/ml) for 30 minutes at 37°C (right panel). Bleb formation was detected by Deep Red Plasma Membrane Stain.