Fibrosis-4 Model Influences Results of Patients with Hepatocellular Carcinoma Undergoing Hepatectomy

Table 2

Univariate and multivariate analysis of factors associated with overall survival of HCC patients with R0 resection.

Factor	Univariate analysis		Multivariate analysis
	OR (95 % CI)	P Value	OR (95 % CI)	P Value
Male	0.88 (0.61-1.2)	0.51
Age	1.0 (0.99-1.01)	0.94
Etiology
HBV	0.89 (0.63-1.3)	0.50
HCV	0.56 (0.18-1.7)	0.31
Child-Pugh Score
A	1 (Reference)
B	1.44 (0.84-2.5)	0.18
MELD	1.106 (0.93-1.106)	0.721
Cirrhosis	1.3 (1.01-1.71)	0.04
AFP	1.0 (1.0-1.0)	0.06
BCLC
0-A	1 (Reference)		1(Reference)
B	1.6 (1.1-1.27)	0.02	1.5(1.04-2.18)	0.03
C	3.65 (2.7-4.9)	<0.01	3.4(2.5-4.66)	<0.01
Tumor
Single	1 (Reference)
Multiple	1.52 (1.12-2.1)	<0.01
Macrovascular invasion	3.55 (2.6-4.8)	<0.01
Microvascular Invasive	1.9 (1.4-2.5)	<0.01	1.5(1.11-2.01)	<0.01
Differentiation
Poor	1 (Reference)
Moderate	0.225 (0.05-1.01)	0.12
Well	0.813 (0.53-1.24)	0.34
Recurrent HCC	0.61 (0.30-1.2)	0.17
Complications III-V	1.7 (1.14-2.54)	0.01	1.6(1.08-2.44)	0.02
Transfusion	1.3 (0.9-1.7)	0.09
AST/ALT	1.15 (1.07-1.23)	<0.01
APRI	1.08 (1.02-1.13)	<0.01
Fibrosis-4	1.04 (1.02-1.07)	<0.01	1.05(1.03-1.08)	<0.01
Lok	1.11 (1.05-1.17)	<0.01
King Score	1.01 (1.01-1.01)	<0.01

ALT: alanine aminotransferase; AST: aspartate aminotransferase. AFP: α-fetoprotein; BCLC: Barcelona Clinic Liver Cancer; APRI: AST-to-platelet ratio index; HBV: hepatitis B virus; HCV: hepatitis C virus. OR: odds ratio; CI: confidence interval; HCC: hepatoma carcinoma.