Fibrosis-4 Model Influences Results of Patients with Hepatocellular Carcinoma Undergoing Hepatectomy

Table 3

Univariate and multivariate analysis of factors associated with disease free survival of HCC patients with R0 resection.

Factor	Univariate analysis		Multivariate analysis
	OR (95 % CI)	P Value	OR (95 % CI)	P Value
Male	0.85 (0.63-1.15)	0.293
Age	0.99 (0.99-1.01)	0.862
Etiology
HBV	0.99 (0.74-1.33)	0.965
HCV	0.54 (0.22-1.31)	0.173
Child Score
A	1 (Reference)
B	1.49 (0.97-2.28)	0.06
MELD	0.999 (0.914-1.90)	0.989
Cirrhosis	1.27 (1.03-1.57)	0.02
AFP	1.00 (1.00-1.00)	0.03
BCLC
0-A	1 (Reference)		1(Reference)
B	1.27 (0.97-1.71)	0.11	1.27(0.95-1.71)	0.11
C	2.73 (2.13-3.50)	<0.01	2.76(2.15-3.56)	<0.01
Tumor
Single	1 (Reference)
Multiple	1.31 (1.02-1.68)	0.03
Macrovascular invasion	2.71 (2.05-3.56)	<0.01
Microvascular Invasive	1.46 (1.15-1.86)	<0.01
Differentiation
Poor	1 (Reference)		1(Reference)
Moderate	0.67 (0.49-0.93)	0.02	0.69(0.49-0.96)	0.025
Well	0.36 (0.15-0.86)	0.021	0.45(0.19-1.06)	0.066
Recurrent HCC	0.86 (0.53-1.38)	0.521
Complications III-V	1.38 (0.97-1.94)	0.07
Transfusion	1.17 (0.91-1.49)	0.224
AST/ALT	1.04 (1.02-1.06)	<0.01
APRI	1.07 (1.03-1.12)	<0.01
Fibrosis-4	1.14 (1.07-1.21)	<0.01	1.05(1.02-1.07)	<0.01
Lok	1.09 (1.04-1.15)	<0.01
King Score	1.01 (1.001-1.004)	<0.01

ALT: alanine aminotransferase; AST: aspartate aminotransferase. AFP: α-fetoprotein; BCLC: Barcelona Clinic Liver Cancer; INR: international normalized ratio; PLT: platelet count. APRI: AST-to-platelet ratio index; HBV: hepatitis B virus; HCV: hepatitis C virus; NBNC: non-B non-C hepatitis virus. IQR: interquartile range; SD: standard deviation.