BioMed Research International / 2018 / Article / Tab 3 / Research Article
Effect of Neoadjuvant Hormone Therapy on Resection Margin and Survival Prognoses in Locally Advanced Prostate Cancer after Prostatectomy Using Propensity-Score Matching Table 3 Cox proportional hazards model for biochemical recurrence before and after propensity score matching.
Variables Before propensity score matching After propensity score matching Univariable analysis Multivariable analysis Univariable analysis HR (95% CI) p valueHR (95% CI) p valueHR (95% CI) p valueNHT plus RRP versus RRP alone 1.05 (0.69-1.61) 0.809 1.03 (0.62-1.72) 0.906 0.84 (0.47-1.49) 0.554 Resection margin 1.51 (0.97-2.36) 0.071 2.14 (1.18-3.86) 0.012 Age ≥65 0.72 (0.46-1.10) 0.128 0.61 (0.34-1.08) 0.091 PSA≥40 2.14 (1.40-3.29) 0.001 2.23 (1.38-3.60) 0.001 3.19 (1.77-5.76) <.001 Biopsy Gleason score sum ≥7 2.35 (1.13-4.87) 0.022 2.77 (0.99-7.73) 0.052 Tumor volume ≥50% 1.78 (1.15-2.75) 0.010 2.50 (1.41-4.44) 0.002 Extracapsular extension 2.47 (1.59-3.85) <.001 2.10 (1.30-3.41) 0.003 5.04 (2.48-10.23) <.001 Seminal vesicle invasion 2.20 (1.44-3.36) <.001 2.42 (1.36-4.30) 0.003 Lymphovascular invasion or emboli 2.35 (1.50-3.68) <.001 1.85 (1.13-3.05) 0.015 3.32 (1.83-6.00) <.001 Perineural invasion 2.04 (1.18-3.51) 0.011 3.61 (1.43-9.17) 0.007 Apex involvement 1.71 (1.05-2.78) 0.031 2.39 (1.26-4.54) 0.008 Lymph node dissection 1.09 (0.47-2.49) 0.845 2.28 (0.55-9.41) 0.256 Neurovascular bundle saving 0.62 (0.39-0.99) 0.045 0.56 (0.30-1.05) 0.070