Effect of Neoadjuvant Hormone Therapy on Resection Margin and Survival Prognoses in Locally Advanced Prostate Cancer after Prostatectomy Using Propensity-Score Matching

Table 3

Cox proportional hazards model for biochemical recurrence before and after propensity score matching.

Variables	Before propensity score matching				After propensity score matching
	Univariable analysis		Multivariable analysis		Univariable analysis
	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
NHT plus RRP versus RRP alone	1.05 (0.69-1.61)	0.809	1.03 (0.62-1.72)	0.906	0.84 (0.47-1.49)	0.554
Resection margin	1.51 (0.97-2.36)	0.071			2.14 (1.18-3.86)	0.012
Age ≥65	0.72 (0.46-1.10)	0.128			0.61 (0.34-1.08)	0.091
PSA≥40	2.14 (1.40-3.29)	0.001	2.23 (1.38-3.60)	0.001	3.19 (1.77-5.76)	<.001
Biopsy Gleason score sum ≥7	2.35 (1.13-4.87)	0.022			2.77 (0.99-7.73)	0.052
Tumor volume ≥50%	1.78 (1.15-2.75)	0.010			2.50 (1.41-4.44)	0.002
Extracapsular extension	2.47 (1.59-3.85)	<.001	2.10 (1.30-3.41)	0.003	5.04 (2.48-10.23)	<.001
Seminal vesicle invasion	2.20 (1.44-3.36)	<.001			2.42 (1.36-4.30)	0.003
Lymphovascular invasion or emboli	2.35 (1.50-3.68)	<.001	1.85 (1.13-3.05)	0.015	3.32 (1.83-6.00)	<.001
Perineural invasion	2.04 (1.18-3.51)	0.011			3.61 (1.43-9.17)	0.007
Apex involvement	1.71 (1.05-2.78)	0.031			2.39 (1.26-4.54)	0.008
Lymph node dissection	1.09 (0.47-2.49)	0.845			2.28 (0.55-9.41)	0.256
Neurovascular bundle saving	0.62 (0.39-0.99)	0.045			0.56 (0.30-1.05)	0.070