Mutation Study of Malaysian Patients with Ornithine Transcarbamylase Deficiency: Clinical, Molecular, and Bioinformatics Analyses of Two Novel Missense Mutations of the OTC Gene

Figure 2

Superimposition between mutant and native structures and hydrogen bond interactions between PALO and residues in CP and ORN binding domains in the native and mutant structures. PALO in the native and mutant structures is shown as green and grey balls and sticks, respectively. Residues in the native and mutant structures are shown as green and grey stick, respectively. New residues interacting with PALO are shown in cyan line. Residues in CP binding domain are shown in magenta line, while residues in ORN binding domain are shown in orange line.