Research Article
UPLC-QTOF MS-Based Serum Metabolomic Profiling Analysis Reveals the Molecular Perturbations Underlying Uremic Pruritus
Table 2
Summary of the potential biomarkers related to UP.
| Number | | TR (min) | Adduct | Metabolites | Formula | VIP | value |
| (1) | 424.34 | 10.14 | M + NH4 | 3-Oxocholic acid | C24H38O5 | 5.27 | 0.03 | (2) | 137.05 | 1.02 | M + H | Phenylacetic acid | C8H8O2 | 5.19 | 0.04 | (3) | 426.36 | 10.66 | M + NH4 | Cholic acid | C24H40O5 | 4.51 | 0.04 | (4) | 290.16 | 3.12 | M + Na | L-Agaritine | C12H17N3O4 | 4.14 | 0.03 | (5) | 568.34 | 10.31 | M + Na | LysoPC(20:3(8Z,11Z,14Z)) | C28H52NO7P | 2.94 | 0.04 | (6) | 269.09 | 1.42 | M + H | L-Homocysteine | C8H16N2O4S2 | 2.82 | 0.03 | (6) | 267.07 | 1.42 | M − H | L-Homocysteine | C8H16N2O4S2 | 1.75 | 0.02 | (7) | 205.16 | 0.64 | M + NH4 | N1-Acetylspermidine | C9H21N3O | 2.67 | 0.01 | (8) | 110.01 | 0.58 | M + H | Hypotaurine | C2H7NO2S | 2.53 | 0.01 | (9) | 130.05 | 1.06 | M + H | Pyroglutamic acid | C5H7NO3 | 2.30 | 0.05 | (10) | 526.29 | 10.27 | M + Na | LysoPE(20:3(5Z,8Z,11Z)/0:0) | C25H46NO7P | 2.24 | 0.02 | (11) | 450.36 | 10.44 | M + Na | Stearoylcarnitine | C25H49NO4 | 1.56 | 0.03 | (12) | 482.33 | 10.11 | M + H | LysoPC(15:0) | C23H48NO7P | 1.38 | 0.04 | (13) | 127.04 | 4.14 | M + Na | 3-Hydroxybutyric acid | C4H8O3 | 1.36 | 0.02 | (14) | 217.10 | 4.70 | M + Na | 4-Aminohippuric acid | C9H10N2O3 | 1.26 | 0.03 | (15) | 570.36 | 10.89 | M + Na | LysoPC(20:2(11Z,14Z)) | C28H54NO7P | 1.20 | 0.03 | (16) | 190.08 | 1.06 | M + H | Kynurenic acid | C10H7NO3 | 1.01 | 0.00 | (17) | 540.33 | 10.57 | M + FA − H | LysoPC(16:0) | C24H50NO7P | 8.32 | 0.01 | (18) | 331.18 | 7.56 | M + FA − H | Androstenedione | C19H26O2 | 4.11 | 0.02 | (19) | 507.21 | 6.53 | M + FA − H | 6-Dehydrotestosterone glucuronide | C25H34O8 | 3.36 | 0.03 | (20) | 283.12 | 6.58 | M − H | p-Cresol glucuronide | C13H16O7 | 2.12 | 0.03 | (21) | 524.28 | 10.27 | M + FA – H | LysoPE(18:1(9Z)/0:0) | C23H46NO7P | 1.69 | 0.04 | (22) | 586.31 | 9.79 | M + FA − H | LysoPC(20:5(5Z,8Z,11Z,14Z,17Z)) | C28H48NO7P | 1.61 | 0.02 |
|
|