Lats1/2-Mediated Alteration of Hippo Signaling Pathway Regulates the Fate of Bone Marrow-Derived Mesenchymal Stem Cells

Figure 6

The effects of high and low expression of Lats1 and Lats2 on the migration of BMSCs. The horizontal migration of BMSCs was determined by the scratch assay (a). The wound width was observed and imaged at 0 and 24 h (200×). The degree of wound healing was shown as bar graph. The vertical migration of BMSCs was determined by the Transwell migration assay (b). The migrating cells below the insert membrane were stained with crystal violet and observed by an inverted phase-contrast microscope (200×). The cell count was shown as bar graph (n = 3; P < 0.05 vs. MSC-GFP, P < 0.05 vs. MSC-shcontrol).

(a)

(b)