The Impact of Pathologic Upgrading of Gleason Score 7 Prostate Cancer on the Risk of the Biochemical Recurrence after Radical Prostatectomy

Table 1

Patients’ characteristics according to the classic categorization of pathologic Gleason score 7 prostate cancer.

	GS 3+4	GS 4+3	p value
N	1094	584
Mean age	66.6 ± 6.5	67.4 ± 6.4	0.010
Preoperative PSA	11.3 ± 11.2	15.4 ± 21.1	<0.001
Preoperative PSA level
<10	691 (69.9%)	303 (51.9%)	<0.001
10–20	286 (26.1%)	155 (26.5%)
>20	117 (10.7%)	126 (21.6%)
Clinical stage
T1c/T2a	971 (88.8%)	486 (83.2%)	0.001
T2b/c	99 (9.0%)	68 (11.6%)
T3-4	24 (2.2%)	30 (5.1%)
Pathologic finding
ECE+	365 (33.4%)	278 (47.6%)	<0.001
SVI+	87 (8.0%)	90 (15.4%)	<0.001
Margin+	416 (38.0%)	238 (40.8%)	0.149
Biochemical recurrence	170 (15.5%)	154 (26.4%)	<0.001

ECE: extracapsular extension; GS: Gleason score; PSA: prostate-specific antigen; SVI: seminal vesicle invasion.