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BioMed Research International
Volume 2018 (2018), Article ID 4528148, 9 pages
Review Article

Right Ventricle Remodeling and Function in Scleroderma Patients

University of Medicine and Pharmacy of Târgu Mureș, Gh. Marinescu Street, No. 38, 540139 Tîrgu Mureș, Romania

Correspondence should be addressed to Iolanda Muntean; moc.liamg@naetnum.adnaloi

Received 1 September 2017; Accepted 12 February 2018; Published 20 March 2018

Academic Editor: Shigeru Kotake

Copyright © 2018 Roxana Cucuruzac et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Scleroderma, known also as systemic sclerosis (SSc), is a severe disease associated with high mortality rates, and right ventricular (RV) remodeling and dysfunction, along with pulmonary artery hypertension (PAH), are among the most important internal organ manifestations of this disease. PAH has a higher prevalence in patients with SSc compared to the general population and represents a significant predictor of mortality in SSc. In patients with SSc, the morphological remodeling and alteration of RV function begin even before the setting of PAH and lead to development of a specific adaptive pattern of the RV which is different from the one recorded in patients with IAPH. These alterations cause worse outcomes and increased mortality rates in SSc patients. Early detection of RV dysfunction and remodeling is possible using modern imaging tools currently available and can indicate the initiation of specific therapeutic measures before installation of PAH. The aim of this review is to summarize the current knowledge related to mechanisms involved in the remodeling and functional alteration of the RV in SSc patients.