Review Article
Right Ventricle Remodeling and Function in Scleroderma Patients
Table 1
Main clinical studies addressing Ssc in patients with or without PAH.
| | Imaging method | Author (year) | Number of patients | Clinical setting | Analyzed parameter | SSc | Controls | |
| | Echocardiography | Pigatto
et al. (2015) [35] | | SSc versus healthy subjects | sPAP (mmHg) | | | <0.0001 | | TAPSE (mm) | | | <0.0001 | | PVR (WU) | | | 0.001 | | global RVLS (%) | | | n.s. | Mukherjee
et al. (2016) [58] | | SSc versus healthy subjects | sPAP (mmHg) | | | 0.0001 | | TAPSE (mm) | | | 0.307 | | PVR (WU) | | | 0.002 | | global RVLS (%) | | | 0.005 | Durmus
et al. (2015) [36] | | SSc versus healthy subjects | sPAP (mmHg) | | | 0.002 | | TAPSE (mm) | | | <0.001 | | global RVLS (%) | | | <0.001 |
| | cMRI | Hachulla
et al. (2009) [69] | | SSc-PAH versus SSc without PAH | RV hypertophy, (%) | 2 (17) | 0 (0) | 0.04 | | RV dilation, (%) | 4 (33) | 7 (17) | 0.25 | | Mean RV EF (%) | 54 (13) | 50 (11) | 0.20 | | Mean RV EDV index (ml/mm2) | 75 (9) | 79 (23) | 0.67 | | Delayed contrast enhancement, (%) | 1 (8) | 10 (26) | 0.42 | Tzelepis
et al. (2007) [70] | | Abnormal versus normal 24-h ECG in SSc | Delayed contrast enhancement, (%) | 15 (78.9) | 9 (52.9) | 0.098 | | Number of enhancing segments, | | | 0.035 | | Enhancement at RV insertion points, (%) | 4 (21.1) | 2 (11.8) | 0.66 | Kelemen
et al. (2015) [46] | | SSc-PAH versus IPAH | RV mass (g) | 58.8 | 65.9 | 0.47 | | RV EDV index (ml/mm2) | 88.1 | 90.1 | 0.83 | | RV EF (%) | 46.0 | 41.6 | 0.29 |
| | Scintigraphy | Papagoras et al. (2014) [65] | | SSc patients | Reversible myocardial perfusion defects, of pts (%) | 21 (60) | - | - |
|
|
sPAP: systolic pulmonary artery pressure; TAPSE: tricuspid annular plane systolic excursion; PVR: pulmonary vascular resistance; RVLS: right ventricle longitudinal strain; EF: ejection fraction; EDV: end diastolic volume.
|
