The Human Carbonic Anhydrase II in Platelets: An Underestimated Field of Its Activity

Figure 3

Postulated map of carbonic anhydrase II activities involving nitrosothiols, nitrate, and nitric oxide metabolism and they influence on platelet aggregation. S-Nitrosocysteine and NO are established platelet aggregation inhibitors [33, 34]. S-Nitrosocysteine is able to act independently of cGMP formation [35]. Dorzolamide and decreased pH increase nitric oxide formation [36]. CA ability to form NO from nitrite inside platelets remains controversial [36]. Nevertheless, Na + in presence of erythrocytic CA II provides platelet cGMP formation [36] (more detailed description in the main text).