In Vivo Release of Vancomycin from Calcium Phosphate Cement

Figure 5

Total amount of VCM released from CPC/VCM and PMMA/VCM into rat tissues in 56 days. In vivo data for day 56 are directly cited from Figure 3 (). In vitro data were calculated by summing values from the elution curves generated following the daily exchange of solvent. The difference between in vitro and in vivo values indicates that CPC/VCM has the potential to continue to release residual VCM after day 56 in vivo. The average value and standard deviation of 10 (in vivo) and 3 (in vitro) of each specimen are shown.