Malignant Gliomas as Second Neoplasms in Pediatric Cancer Survivors: Neuropathological Study

Figure 3

Details of neoplastic immunophenotype: (a) GFAP-negative tumor cells and immunopositive reactive astrocytes (P3, GFAP, 400x), (b) moderate GFAP staining in neoplastic cells (P1, GFAP, 200x), (c) high proliferative index in glioblastoma (P3, Ki-67, 200x), (d) strong nestin expression in recurrent tumor (P5r, nestin, 200x), (e) perivascular subpopulation of synaptophysin-reactive cells (P2, synaptophysin, 400x), (f) intense vimentin staining in recurrent GFAP-negative glioblastoma (P5r, vimentin, 200x).

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