Malignant Gliomas as Second Neoplasms in Pediatric Cancer Survivors: Neuropathological Study

Table 2

Immunophenotype and molecular profiling of analyzed tumors.

	P1	P2	P3	P4	P5	P5 rec
GFAP	++	+	Focal +	Focal +	Focal +	Focal +
Vimentin	+++	+++	++	++	++	+++
Synaptophysin	-	Focal +	-	-	-	Focal +
EMA	-	NA	-	NA	-	Focal +
Nestin	+	-	+	Focal +	Focal +	+++
Olig2	+	+	+	+	-	+
P53	+	+	+	NA	+	+
EGFR	++	+	++	NA	++	++
HER3	++	++	++	NA	NA	++
PTEN	+++	+++	+++	NA	+++	+++
PI3Kp110	++	++	++	NA	++	+++
pAKT	++	-	++	NA	+	+++
p-mTOR	-	-	-	NA	+	++
P70S6K	-	-	-	NA	+	++
MGMT	High	High	High	NA	Low	Low
IDH1	-	-	-	NA	-	-
ATRX	+	+	+	NA	+	+
Ki67	25%	50%	15%	NA	20%	40%

Abbreviations. GFAP: glial fibrillary acidic protein, EMA: epithelial membrane protein, EGFR: epidermal growth factor, rec: recurrent, NA: not available.