Ligustilide Ameliorates Memory Deficiency in APP/PS1 Transgenic Mice via Restoring Mitochondrial Dysfunction

Figure 1

LIG improved the memory deficiency of APP/PS1 mice. (a) Escape latency from five consecutive days of tests. (b) Times of the traversing the platform position. (c) Time spent in the quadrant of the platform in the probe trial. (d) The swimming speed of each respective group on the sixth day. (e) The swimming paths of each respective group on the sixth day. (f) Spontaneous alternation rate of each respective group in the Y-maze test. Data are presented as the mean ± SEM (n = 12 per group). WT: 9-month-old wild-type C57 male mice; APP/PS1: 9-month-old APP/PS1 male mice; LIG10: 9-month-old APP/PS1 mice + LIG (10 mg/kg); LIG40: 9-month-old APP/PS1 mice + LIG (40 mg/kg). p < 0.05; p < 0.01 versus 9-month-old wild-type C57 male mice; p < 0.05; p < 0.01 versus 9-month-old APP/PS1 mice.

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