Ligustilide Ameliorates Memory Deficiency in APP/PS1 Transgenic Mice via Restoring Mitochondrial Dysfunction

Figure 3

LIG regulated the levels of A degrading enzymes in the brains of APP/PS1 transgenic mice. We used COX-IV as a loading control for mitochondria proteins. (a) The levels of IDE, NEP, and PreP were detected in the hippocampus. (b) The levels of IDE, NEP, and PreP were detected in the cortex (n = 6 per group). (c) The levels in mitochondria separated from the hippocampus and cortex detected using ELISA kit. Data are presented as the mean ± SEM (n = 6 per group). WT: 9-month-old wild-type C57 male mice; APP/PS1: 9-month-old APP/PS1 male mice; LIG10: 9-month-old APP/PS1 mice + LIG (10 mg/kg); LIG40: 9-month-old APP/PS1 mice + LIG (40 mg/kg). p < 0.05; p < 0.01 versus 9-month-old wild-type C57 male mice; p < 0.05; p < 0.01 versus 9-month-old APP/PS1 mice.

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