Ligustilide Ameliorates Memory Deficiency in APP/PS1 Transgenic Mice via Restoring Mitochondrial Dysfunction

Figure 7

LIG protected the synapses in APP/PS1 transgenic mice. (a) The levels of SYN 1, PSD-95, and SYN detected in the hippocampus. (b) The levels of SYN 1, PSD-95, and SYN detected in cortex. Data are presented as the mean ± SEM (n = 6 per group). WT: 9-month-old wild-type C57 male mice; APP/PS1: 9-month-old APP/PS1 male mice; LIG10: 9-month-old APP/PS1 mice + LIG (10 mg/kg); LIG40: 9-month-old APP/PS1 mice + LIG (40 mg/kg). p < 0.05; p < 0.01 versus 9-month-old wild-type C57 male mice; p < 0.05; p < 0.01 versus 9-month-old APP/PS1 mice.

(a)

(b)