Using IVIM-MRI and R2⁎ Mapping to Differentiate Early Stage Liver Fibrosis in a Rat Model of Radiation-Induced Liver Fibrosis

Figure 1

Pathological changes of left lobe (control) and right lobes at different fibrosis stages after radiation. Representative Hematoxylin eosin staining (HE, 20×), masson trichrome staining (MT, 20×), and prussian blue staining (PB, 20×) of liver sections. The lobular structure of left lobe is intact. The hepatic cord is orderly. The central vein is surrounded by the cords of hepatocytes which radiate out in all directions (a). Cytoplasm rarefaction and hepatocyte swelling can be seen in stage F0 (b). Infiltration of inflammatory cell and spotty necrosis could be seen in hepatic lobules at stage F1(c). Hyperplasia of small bile ducts and deposition of collagen fibers can be seen in portal areas at stage F2 (d). From stage F0 to F2, an increased amount of blue-stained fibrous tissues deposits in the portal areas and encompasses the central veins (f-h). No blue particles can be seen in the left lobe (i). An increased amount of blue-stained iron particles deposit is seen in the hepatocytes and macrophages from stage F0 to F2 (j-l).

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