Bauhinia variegata candida Fraction Induces Tumor Cell Death by Activation of Caspase-3, RIP, and TNF-R1 and Inhibits Cell Migration and Invasion In Vitro

Figure 3

FR3 inhibited wound closure of the HeLa cell monolayer after 72 hours of treatment (a) in 70% () and decreased the expression of active MMP-2 in the supernatant of these cells (b). FR3 inhibited the migration of HeLa cells (15 ug/ml and 30 ug/ml) by the Boyden Chamber assay, as well as treatment with Cisplatin (15 ug/ml) for 24 hours (c) and inhibited the invasion of HeLa cells treated for 24 hours using Matrigel (d). The significant difference with values.   indicates statistically significant differences between treatment and control with value of p ≤ 0.001.   indicates statistically significant differences between treatment and control with value of p ≤ 0.005.   represents the significant difference with a value of p ≤ 0.05. Different letters indicate statistically significant differences between each treatment with p ≤ 0.0001.

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