Doxazosin and Carvedilol Treatment Improves Hepatic Regeneration in a Hamster Model of Cirrhosis

Figure 2

Analysis of the histological structure of the hepatic parenchyma after treatment with α/β adrenoblockers, carried out with H&E, PAS and Sirius red. (a), (f), and (k) Intact animals. (b), (g), and (l) Group with cirrhosis. (c), (h), and (m) Placebo group. (d), (i), and (n) Group treatment with doxazosin. (e), (j), and (o) Group treatment with carvedilol. White arrow, indicated fibrotic area, dotted line indicated inflammatory infiltrate and cellular damage, black arrow indicated steatosis, black arrowhead indicated swollen spherical hepatocytes and cellular edema, and asterisks indicated regeneration nodules.

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