Doxazosin and Carvedilol Treatment Improves Hepatic Regeneration in a Hamster Model of Cirrhosis
Expression of the markers of regulation of extracellular matrix and proliferation or carcinogenesis, showing the degree of regeneration. (a) The electrophoresis gel shows the different markers evaluated by primers in endpoint PCR (MMP-13, TIMP-2, α-FP, HGF, CK-7, and c-Myc). (b) Quantitative analysis by qPCR shows the level relative expression (axis “Y”) for each marker (MMP-13, TIMP-2, α-FP, HGF, CK-7, and c-Myc). It was evaluated with analysis of variance test with the Tukey post hoc. The bars represent the mean value ± SD. ;; of the treated groups in relation to the intact and cirrhosis (without treatment) groups (n=5).
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