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BioMed Research International
Volume 2018, Article ID 4714836, 8 pages
https://doi.org/10.1155/2018/4714836
Research Article

Association of NLRP1 and NLRP3 Polymorphisms with Psoriasis Vulgaris Risk in the Chinese Han Population

1Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China
2Department of Bioinformatics, Harbin Medical University, Harbin 150001, China

Correspondence should be addressed to Yuzhen Li; nc.moc.liamdem@nehzuyil

Received 12 September 2017; Revised 29 January 2018; Accepted 13 February 2018; Published 3 April 2018

Academic Editor: Ruben Queiro-Silva

Copyright © 2018 Pei Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. To clarify the association between the single nucleotide polymorphisms (SNPs) in the NLRP1 and NLRP3 and Psoriasis Vulgaris (PsV) in the Chinese Han population. Methods. We genotyped eight SNPs, four from NLRP1 (rs8079034, rs11651270, rs11657747, and rs878329) and NLRP3 (rs7512998, rs3806265, rs10754557, and rs10733113) each in 540 patients with PsV and 612 healthy controls in the Chinese Han population using an improved multiplexed ligation detection reaction (iMLDR) method. The genotype and haplotype frequencies were analyzed using a case-control study design. Results. We identified two SNPs, rs3806265 and rs10754557, in NLRP3 that were significantly associated with PsV. The genotype distribution of the rs3806265 SNP was significantly different between cases and controls (; OR = 0.791; 95% CI = 0.627–0.998). In the recessive model, the genotype distribution of the rs10754557 SNP was significantly different between cases and controls (; OR = 1.277; 95% CI = 0.987–1.652). The haplotype analysis of rs3806265 and rs10754557 also presented a significant association of TA haplotype with PsV (; ). Conclusion. NLRP3 may play a role in PsV susceptibility in the Chinese Han population.