Association of NLRP1 and NLRP3 Polymorphisms with Psoriasis Vulgaris Risk in the Chinese Han Population
Table 4
The single SNP association studies result of NLRP3 on the risk of PV.
Genotype
Cases ()
Controls ()
value
Adjusted value
Statistical model
OR (95% CI)
rs7512998
TT
450 (83.3%)
524 (85.6%)
Additive
0.3710
0.4540
TC
90 (16.7%)
86 (14.1%)
Dominant
0.4488
0.4969
1.146
CC
0 (0.0%)
2 (0.3%)
Recessive
--
0.9998
()
T/C
990/90
1134/90
0.5235
0.5760
Heterozygous
0.3846
0.4227
91.7%/8.3%
92.6%/7.4%
rs3806265
TT
166 (30.8%)
156 (25.5%)
Additive
0.1191
0.1157
TC
278 (51.5%)
308 (50.3%)
Dominant
0.1614
0.1613
0.791
CC
96 (17.7%)
144 (24.2%)
Recessive
0.0595
0.0629
()
T/C
610/470
620/604
0.0451
0.0474
Heterozygous
0.7821
0.8072
56.5%/43.5%
50.7%/49.3%
rs10754557
GG
40 (7.4%)
52 (8.5%)
Additive
0.1054
0.1019
GA
200 (37.0%)
274 (44.8%)
Dominant
0.6298
0.6516
1.277
AA
300 (55.6%)
286 (46.7%)
Recessive
0.0344
0.0352
()
G/A
360/800
378/846
0.0614
0.0655
Heterozygous
0.0595
0.0577
25.9%/74.1%
30.9%/69.1%
rs10733113
GG
474 (87.8%)
552 (90.2%)
Additive
--
0.9999
GA
66 (12.2%)
60 (9.8%)
Dominant
0.3540
0.4282
1.263
AA
0 (0.0%)
0 (0.0%)
Recessive
--
0.9998
()
G/A
1014/66
1164/60
0.3540
0.4282
Heterozygous
0.3540
0.4282
93.9%/6.1%
95.1%/4.9%
, number; , model-based statistical value; , value adjusted by permutation; OR, odds ratio (we used the major allele as the reference allele to calculate the OR); 95% CI, 95% confidence interval; indicates the significant association.
