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BioMed Research International
Volume 2018, Article ID 4793971, 10 pages
https://doi.org/10.1155/2018/4793971
Research Article

MicroRNA-219-5p Promotes Tumor Growth and Metastasis of Hepatocellular Carcinoma by Regulating Cadherin 1

1Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute, Fudan University, 12 Urumqi Road (M), Shanghai 200040, China
2Institutes of Biomedical Sciences, Fudan University, 131 Dong An Road, Shanghai 200032, China

Correspondence should be addressed to Hu-Liang Jia; moc.361@1-lbj, Qiong-Zhu Dong; nc.ude.naduf@gnodhzq, and Lun-Xiu Qin; nc.ude.naduf@xlniq

Received 16 January 2018; Accepted 19 March 2018; Published 15 May 2018

Academic Editor: Dimitrios P. Bogdanos

Copyright © 2018 Jing Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

MicroRNAs play significant roles in the development of cancer and may serve as promising therapeutic targets. In our previous work, miR-219-5p was identified as one of the important metastasis-related microRNAs in HCC. Here we demonstrated that miR-219-5p expression was elevated in HCC tissues and was associated with vascular invasion and dismal prognosis. In multivariate analysis, miR-219-5p was identified as an independent prognostic indicator for HCC patients. Functional mechanism analyses showed that miR-219-5p promoted HCC cell proliferation and invasion in in vitro, as well as in vivo, tumor growth and metastasis in nude mice models bearing human HCC tumors. In addition, cadherin 1 (CDH1) was revealed to be a downstream target of miR-219-5p in HCC cells. In conclusion, miR-219-5p promotes tumor growth and metastasis of HCC by regulating CDH1 and can serve as a prognostic marker for HCC patients.