Table 3: Univariate and multivariate analyses of factors associated with recurrence in patients with hepatocellular carcinoma (HCC).

FeaturesRecurrence
Univariate Multivariate
HR95% CI

SexNA
Male versus female0.331NA
AgeNA
>50 versus ≤500.832NA
HBsAgNA
Positive versus negative0.0430.7610.392~1.4760.419
AFPNA
20 ng/ml versus ≤20 ng/ml0.615NA
Liver cirrhosisNA
Yes versus no0.065NA
Tumor sizeNA
>5 cm versus ≤5 cm<0.0011.7441.274~2.388<0.001
Tumor encapsulationNA
Yes versus no0.671NA
Tumor numberNA
Multiple versus single0.0101.5790.751~3.3180.228
Vascular invasionNA
Yes versus no0.0141.8701.205~2.9020.005
Tumor differentiationNA
I~II versus III~IV0.539NA
miR-219-5pNA
High versus low0.0141.6631.072~2.5770.023

Abbreviations. HBsAg: hepatitis B surface antigen; HR: hazard ratio; CI: confidence interval.