Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study

Figure 2

Time course of intraventricular pressure rise during IVC and the underlying increase of tension in LV wall under control conditions. (a) Simulated rise of intraventricular pressure and its comparison with digitalized experimental records published by Curtiss et al. [14], Manolas [15], and Kern et al. [16]. Note that the duration of IVK ( ms) and (1780 mm Hg/s) agrees with clinically measured values (61 ms, 63 ms, 61 ms, and 1790 mm Hg/s, 1730 mm Hg/s, and 2130 mm Hg/s, resp.). (b) Simulated rise of (active) stress along the direction of myocytes in the individual layers. The colours of individual lines (from blue to red) denote the layers of LV wall (from endocardium to epicardium - see Figure 1).

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