Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study

Figure 3

Effect of transmural differences in the electromechanical delay (EMD) and in the myocyte shortening velocity (MSV) on the rate of ventricular pressure rise , duration of isovolumic contraction (IVC) and the underlying tension in LV wall. (a) Simulated increase of intraventricular pressure under control conditions and when either EMD, or MSV, or both were set constant in all ventricular layers. (b) Simulated rise of tension in individual layers when EMD was set constant across the LV wall. (c) Simulated rise of tension in individual layers when MSV was set constant across the LV wall. Colours of the individual lines in (b) and (c) denote the layers of LV wall from subendocardium (blue) to subepicardium (red).

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