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BioMed Research International
Volume 2018, Article ID 4806534, 7 pages
https://doi.org/10.1155/2018/4806534
Review Article

Noncaloric Sweeteners in Children: A Controversial Theme

1Escuela de Nutrición y Dietética, Facultad de Ciencias de la Salud, Universidad San Sebastián, Santiago de Chile, Chile
2Carrera de Nutrición y Dietética, Facultad de Medicina, Universidad Andres Bello, Sede Concepción, Talcahuano, Chile
3Escuela de Nutrición y Dietética, Facultad de Medicina, Universidad Andres Bello, Santiago, Chile
4Faculdade de Medicina/FAGOC, Ubá, MG, Brazil
5Universidade Estadual de Minas Gerais (UEMG), Barbacena, MG, Brazil

Correspondence should be addressed to Samuel Durán Agüero; lc.ssu@narud.leumas

Received 7 June 2017; Revised 5 September 2017; Accepted 19 September 2017; Published 8 January 2018

Academic Editor: Manuel Velasco

Copyright © 2018 Samuel Durán Agüero et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Kim, G. Lee, H. S. Lim et al., “Safety assessment of 16 sweeteners for the Korean population using dietary intake monitoring and poundage method,” Food Additives & Contaminants: Part A, vol. 34, no. 9, pp. 1500–1509, 2017. View at Publisher · View at Google Scholar
  2. A. Roberts, “The safety and regulatory process for low calorie sweeteners in the United States,” Physiology and Behavior, vol. 164, pp. 439–444, 2016. View at Publisher · View at Google Scholar · View at Scopus
  3. “Norma general del CODEX para los aditivos alimentarios Revisión 2011 (GSFA, CODEXSTAN 192-1995),” http://www.fao.org/gsfaonline/docs/CXS_192s.pdf.
  4. “Statement of EFSA on the scientific evaluation of two studies related to the safety of artificial sweeteners,” EFSA Journal, vol. 9, no. 2, p. 2089, 2011. View at Publisher · View at Google Scholar
  5. “Food Additives & Ingredients,” https://www.fda.gov/Food/IngredientsPackagingLabeling/FoodAdditivesIngredients/default.htm.
  6. D. M. Martyn, A. P. Nugent, B. A. McNulty et al., “Dietary intake of four artificial sweeteners by Irish pre-school children,” Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, vol. 33, no. 4, pp. 592–602, 2016. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Huvaere, S. Vandevijvere, M. Hasni, C. Vinkx, and J. van Loco, “Dietary intake of artificial sweeteners by the belgian population,” Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, vol. 29, no. 1, pp. 54–65, 2012. View at Google Scholar · View at Scopus
  8. A. J. O’Sullivan, S. Pigat, C. O’Mahony, M. J. Gibney, and A. I. McKevitt, “Longitudinal modelling of the exposure of young UK patients with PKU to acesulfame K and sucralose,” Food Additives & Contaminants: Part A, vol. 34, no. 11, pp. 1863–1874, 2017. View at Publisher · View at Google Scholar
  9. P. J. Huth, V. L. Fulgoni, D. R. Keast, K. Park, and N. Auestad, “Major food sources of calories, added sugars, and saturated fat and their contribution to essential nutrient intakes in the U.S. diet: Data from the national health and nutrition examination survey (2003-2006),” Nutrition Journal , vol. 12, no. 1, article no. 116, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. B. M. Popkin and C. Hawkes, “Sweetening of the global diet, particularly beverages: Patterns, trends, and policy responses,” The Lancet Diabetes & Endocrinology, vol. 4, no. 2, pp. 174–186, 2016. View at Publisher · View at Google Scholar · View at Scopus
  11. S. D. Agüero, A. V. Leiva, G. M. Illanes et al., “Association between stevia sweetener consumption and nutritional status in university students,” Nutricion Hospitalaria, vol. 32, no. 1, pp. 362–366, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. D. S. Aguero, E. B. Batten, M. d. R. Noel et al., “Asociación entre edulcorantes no nutritivos y riesgo de obesidad en estudiantes universitarios de Latinoamérica,” Revista médica de Chile, vol. 143, no. 3, pp. 367–373, 2015. View at Publisher · View at Google Scholar
  13. S. D. Aguero, E. B. Batten, P. R. N. Mdel, K. C. Arrivillaga, J. S. de Ariza, J. R. Cornwall et al., “Association between non-nutritive sweeteners and obesity risk among university students in Latin America,” Rev Med Chile, vol. 143, no. 3, pp. 367–73, 2015. View at Google Scholar
  14. S. D. Aguero, G. Onate, and H. P. Rivera, “Consumption of non-nutritive sweeteners and nutritional status in 10-16 year old students,” Archivos Argentinos de Pediatria, vol. 112, no. 3, 2014. View at Publisher · View at Google Scholar
  15. L. L. C. Cagnasso and M. Valencia, “Edulcorantes no nutritivos en bebidas sin alcohol: estimación de la ingesta en niños y adolescentes. Arch Argent Pediatr,” in Archivos Argentinos De Pediatria, vol. 105, pp. 517–521, 2007. View at Google Scholar
  16. R. d. Zanini, C. L. Araújo, and J. Martínez-Mesa, “Utilização de adoçantes dietéticos entre adultos em Pelotas, Rio Grande do Sul, Brasil: um estudo de base populacional,” Cadernos de Saúde Pública, vol. 27, no. 5, pp. 924–934, 2011. View at Publisher · View at Google Scholar
  17. J. I. Baile, “Obese but malnourished: a serious problem in Latin America,” Revista Médica de Chile, vol. 143, no. 10, pp. 1361-1362, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. D. Kirkland and D. Gatehouse, “"Aspartame: a review of genotoxicity data",” Food and Chemical Toxicology, vol. 84, pp. 161–168, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. “Programa del niño menor de 2 años. Chile,” http://www.enfermeriaaps.com/portal/wp-content/uploads/2016/01/Gu%C3%ADa-de-alimentaci%C3%B3n-del-ninoa-menor-de-2-a%C3%B1os-Gu%C3%ADa-de-alimentaci%C3%B3n-hasta-la-adolescencia.-MINSAL-Chile-2015.pd.
  20. Ministerio de Salud de la Nación. Sobrepeso y obesidad en niños y adolescentes. Orientaciones para su prevención, diagnóstico y tratamiento en Atención Primaria de la Salud, vol. 40, Buenos Aires: Ministerio de Salud de la Nación, 1st edition, 2013. View at Publisher · View at Google Scholar
  21. Journal of the Pakistan Medical Association, Artificial sweeteners: safe or unsafe? Qurrat-ul-Ain, Khan SA, 2015.
  22. R. J. Brown, M. A. de Banate, and K. I. Rother, “Artificial sweeteners: a systematic review of metabolic effects in youth,” International Journal of Pediatric Obesity, vol. 5, no. 4, pp. 305–312, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. C. Fitch and K. S. Keim, “Position of the Academy of Nutrition and Dietetics: use of nutritive and nonnutritive sweeteners,” Journal of the Academy of Nutrition and Dietetics, vol. 112, no. 5, pp. 739–758, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. L. Sedova, O. Šeda, L. Kazdová et al., “Sucrose feeding during pregnancy and lactation elicits distinct metabolic response in offspring of an inbred genetic model of metabolic syndrome,” American Journal of Physiology-Renal Physiology, vol. 292, no. 5, pp. E1318–E1324, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. A. R. Hirsch, “Migraine triggered by sucralose - A case report [1],” Headache: The Journal of Head and Face Pain, vol. 47, no. 3, p. 447, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. V. L. Grotz, “Sucralose and Migraine,” Headache: The Journal of Head and Face Pain, vol. 48, no. 1, pp. 164-165, 2008. View at Publisher · View at Google Scholar
  27. E. G. Abegaz and R. G. Bursey, “Formaldehyde, aspartame, migraines: A possible connection,” Dermatitis, vol. 20, no. 3, pp. 176-177, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. S. Taheri, “Effect of exclusion of frequently consumed dietary triggers in a cohort of children with chronic primary headache,” Nutrition and Health, vol. 23, no. 1, pp. 47–50, 2017. View at Publisher · View at Google Scholar
  29. F. Imamura, L. O'Connor, Z. Ye et al., “Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: Systematic review, meta-analysis, and estimation of population attributable fraction,” British Journal of Sports Medicine, vol. 50, no. 8, pp. 496–504, 2016. View at Publisher · View at Google Scholar · View at Scopus
  30. R. H. Striegel-Moore, D. Thompson, S. G. Affenito et al., “Correlates of beverage intake in adolescent girls: The National Heart, Lung, and Blood Institute Growth and Health Study,” Journal of Pediatrics, vol. 148, no. 2, pp. 183–187, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. R. P. Watowicz, S. E. Anderson, G. L. Kaye, and C. A. Taylor, “Energy contribution of beverages in us children by age, weight, and consumer status,” Childhood Obesity, vol. 11, no. 4, pp. 475–483, 2015. View at Publisher · View at Google Scholar · View at Scopus
  32. T. V. E. Kral, A. J. Stunkard, R. I. Berkowitz, V. A. Stallings, R. H. Moore, and M. S. Faith, “Beverage consumption patterns of children born at different risk of obesity,” Obesity, vol. 16, no. 8, pp. 1802–1808, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Durán A, M. Quijada M, L. Silva V, N. Almonacid M, M. Berlanga Z, and M. Rodríguez N, “Niveles de ingesta diaria de edulcorantes no nutritivos en escolares de la región de valparaíso,” Revista chilena de nutrición, vol. 38, no. 4, pp. 444–449, 2011. View at Publisher · View at Google Scholar
  34. European Food Safety Authority, “Refined exposure assessment for Ponceau 4R (E 124),” EFSA Journal, vol. 13, no. 4, 2015. View at Publisher · View at Google Scholar
  35. M. I. Lefterova and M. A. Lazar, “New developments in adipogenesis,” Trends in Endocrinology and Metabolism, vol. 20, no. 3, pp. 107–114, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. B. R. Simon, S. D. Parlee, B. S. Learman et al., “Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors,” The Journal of Biological Chemistry, vol. 288, no. 45, pp. 32475–32489, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Pandurangan, J. Park, and E. Kim, “Aspartame downregulates 3T3-L1 differentiation,” In Vitro Cellular and Developmental Biology - Animal, vol. 50, no. 9, pp. 851–857, 2014. View at Publisher · View at Google Scholar · View at Scopus
  38. E. Lim, J. Y. Lim, J.-H. Shin et al., “D-Xylose suppresses adipogenesis and regulates lipid metabolism genes in high-fat diet-induced obese mice,” Nutrition Research, vol. 35, no. 7, pp. 626–636, 2015. View at Publisher · View at Google Scholar · View at Scopus
  39. G. K. W. Frank, T. A. Oberndorfer, A. N. Simmons et al., “Sucrose activates human taste pathways differently from artificial sweetener,” NeuroImage, vol. 39, no. 4, pp. 1559–1569, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. A. Jimenez-Cruz, L. M. Gomez-Miranda, and M. Bacardi-Gascon, “Interacting generalized dark energy and reconstruction of scalar field models,” Modern Physics Letters A, vol. 28, no. 38, Article ID 1350180, 15 pages, 2013. View at Publisher · View at Google Scholar
  41. A. Cantoral, M. M. Téllez-Rojo, A. S. Ettinger, H. Hu, M. Hernández-Ávila, and K. Peterson, “Early introduction and cumulative consumption of sugar-sweetened beverages during the pre-school period and risk of obesity at 8-14 years of age,” Pediatric Obesity, vol. 11, no. 1, pp. 68–74, 2016. View at Publisher · View at Google Scholar · View at Scopus
  42. R. J. Scharf and M. D. DeBoer, “Sugar-Sweetened Beverages and Children's Health,” Annual Review of Public Health, vol. 37, pp. 273–293, 2016. View at Publisher · View at Google Scholar · View at Scopus
  43. S. B. D. Torre, A. Keller, J. L. Depeyre, and M. Kruseman, “Sugar-Sweetened Beverages and Obesity Risk in Children and Adolescents: A Systematic Analysis on How Methodological Quality May Influence Conclusions,” Journal of the Academy of Nutrition and Dietetics, vol. 116, no. 4, pp. 638–659, 2016. View at Publisher · View at Google Scholar · View at Scopus
  44. L. T. Morenga, S. Mallard, and J. Mann, “Dietary sugars and body weight: Systematic review and meta-analyses of randomised controlled trials and cohort studies,” BMJ, vol. 345, no. 7891, Article ID e7492, 2013. View at Publisher · View at Google Scholar · View at Scopus
  45. M. B. Vos, J. L. Kaar, J. A. Welsh et al., “Added sugars and cardiovascular disease risk in children: A scientific statement from the American Heart Association,” Circulation, vol. 135, no. 19, pp. e1017–e1034, 2017. View at Publisher · View at Google Scholar · View at Scopus
  46. J. C. de Ruyter, M. R. Olthof, J. C. Seidell, and M. B. Katan, “A trial of sugar-free or sugar-sweetened beverages and body weight in children,” The New England Journal of Medicine, vol. 367, no. 15, pp. 1397–1406, 2012. View at Publisher · View at Google Scholar · View at Scopus
  47. C. L. Williams, B. A. Strobino, and J. Brotanek, “Weight control among obese adolescents: A pilot study,” International Journal of Food Sciences and Nutrition, vol. 58, no. 3, pp. 217–230, 2007. View at Publisher · View at Google Scholar · View at Scopus
  48. P. E. Miller and V. Perez, “Low-calorie sweeteners and body weight and composition: A meta-analysis of randomized controlled trials and prospective cohort studies,” American Journal of Clinical Nutrition, vol. 100, no. 3, pp. 765–777, 2014. View at Publisher · View at Google Scholar · View at Scopus
  49. M. B. Katan, J. C. De Ruyter, L. D. J. Kuijper, C. C. Chow, K. D. Hall, and M. R. Olthof, “Impact of masked replacement of sugar-sweetened with sugar-free beverages on body weight increases with initial bmi: Secondary analysis of data from an 18 month double-blind trial in children,” PLoS ONE, vol. 11, no. 7, Article ID e0159771, 2016. View at Publisher · View at Google Scholar · View at Scopus
  50. J. Foreyt, R. Kleinman, R. J. Brown, and R. Lindstrom, “The Use of Low-Calorie Sweeteners by Children: Implications for Weight Management,” Journal of Nutrition, vol. 142, no. 6, 2012. View at Publisher · View at Google Scholar · View at Scopus
  51. C. B. Ebbeling, H. A. Feldman, and V. R. Chomitz, “A randomized trial of sugar-sweetened beverages and adolescent body weight,” The New England Journal of Medicine, vol. 367, no. 15, pp. 1407–1416, 2012. View at Publisher · View at Google Scholar · View at Scopus
  52. R. A. Forshee and M. L. Storey, “Total beverage consumption and beverage choices among children and adolescents,” International Journal of Food Sciences and Nutrition, vol. 54, no. 4, pp. 297–307, 2003. View at Publisher · View at Google Scholar · View at Scopus
  53. T. M. O'Connor, S.-J. Yang, and T. A. Nicklas, “Beverage intake among preschool children and its effect on weight status,” Pediatrics, vol. 118, no. 4, pp. e1010–e1018, 2006. View at Publisher · View at Google Scholar · View at Scopus
  54. Y. Zhu, S. F. Olsen, P. Mendola et al., “Maternal consumption of artificially sweetened beverages during pregnancy, and offspring growth through 7 years of age: a prospective cohort study,” International Journal of Epidemiology, vol. 46, no. 5, pp. 1499–1508, 2017. View at Publisher · View at Google Scholar
  55. F. Ali, “Consumption of artificial sweeteners in pregnancy increased overweight risk in infants,” Archives of Disease in Childhood. Education and Practice Edition, Article ID 312618, p. 2017, 2017. View at Publisher · View at Google Scholar
  56. A. E. Reid, B. F. Chauhan, R. Rabbani et al., “Early exposure to nonnutritive sweeteners and long-term metabolic health: A systematic review,” Pediatrics, vol. 137, no. 3, Article ID e20153603, 2016. View at Publisher · View at Google Scholar · View at Scopus
  57. N. T. Mueller, D. R. Jacobs, R. F. MacLehose et al., “Consumption of caffeinated and artificially sweetened soft drinks is associated with risk of early menarche,” American Journal of Clinical Nutrition, vol. 102, no. 3, pp. 648–654, 2015. View at Publisher · View at Google Scholar · View at Scopus
  58. R. E. Kleinman, “Aspartic acid, phenylalanine, and early menarche,” American Journal of Clinical Nutrition, vol. 102, no. 6, pp. 1617-1618, 2015. View at Publisher · View at Google Scholar · View at Scopus
  59. J. Carwile, W. Willett, D. Spiegelman et al., “Sugar-sweetened beverage consumption and age at menarche in a prospective study of US girls,” Human Reproduction, vol. 30, no. 3, pp. 675–683, 2015. View at Publisher · View at Google Scholar
  60. S. E. Swithers, “Artificial sweeteners produce the counterintuitive effect of inducing metabolic derangements,” Trends in Endocrinology & Metabolism, vol. 24, no. 9, pp. 431–441, 2013. View at Publisher · View at Google Scholar · View at Scopus
  61. Y. M. Terry-McElrath, L. Turner, A. Sandoval, L. D. Johnston, and F. J. Chaloupka, “Commercialism in US elementary and secondary school nutrition environments trends from 2007 to 2012,” JAMA Pediatrics, vol. 168, no. 3, pp. 234–242, 2014. View at Publisher · View at Google Scholar · View at Scopus
  62. P. A. M. Smeets, P. Weijzen, C. de Graaf, and M. A. Viergever, “Consumption of caloric and non-caloric versions of a soft drink differentially affects brain activation during tasting,” NeuroImage, vol. 54, no. 2, pp. 1367–1374, 2011. View at Publisher · View at Google Scholar · View at Scopus
  63. A. Romo-Romo, C. A. Aguilar-Salinas, G. X. Brito-Cordova, R. A. G. Diaz, D. V. Valentin, and P. Almeda-Valdes, “Effects of the non-nutritive sweeteners on glucose metabolism and appetite regulating hormones: Systematic review of observational prospective studies and clinical Trials,” PLoS ONE, vol. 11, no. 8, Article ID 0161264, 2016. View at Publisher · View at Google Scholar · View at Scopus
  64. Q.-P. Wang, Y. Q. Lin, L. Zhang et al., “Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response,” Cell Metabolism, vol. 24, no. 1, pp. 75–90, 2016. View at Publisher · View at Google Scholar · View at Scopus
  65. J. Suez, T. Korem, and D. Zeevi, “Artificial sweeteners induce glucose intolerance by altering the gut microbiota,” Nature, vol. 514, no. 7521, pp. 181–186, 2014. View at Publisher · View at Google Scholar
  66. K. Daly, A. C. Darby, and S. P. Shirazi-Beechey, “Low calorie sweeteners and gut microbiota,” Physiology and Behavior, vol. 164, pp. 494–500, 2016. View at Publisher · View at Google Scholar · View at Scopus
  67. M. B. Abou-Donia, E. M. El-Masry, A. A. Abdel-Rahman, R. E. McLendon, and S. S. Schiffman, “Splenda alters gut microflora and increases intestinal P-glycoprotein and cytochrome P-450 in male rats,” Journal of Toxicology and Environmental Health A: Current Issues, vol. 71, no. 21, pp. 1415–1429, 2008. View at Publisher · View at Google Scholar · View at Scopus
  68. K. Norman, “Of mice and men--how saccharin induces glucose intolerance by altering the gut microbiota,” in Zeitschrift Fur Gastroenterologie, vol. 52, p. 1494, 1493, 2014. View at Google Scholar
  69. X. Bian, L. Chi, B. Gao et al., “The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in CD-1 mice,” PLoS ONE, vol. 12, no. 6, p. e0178426, 2017. View at Publisher · View at Google Scholar
  70. P. Gupta, N. Gupta, A. P. Pawar, S. S. Birajdar, A. S. Natt, and H. P. Singh, “Role of Sugar and Sugar Substitutes in Dental Caries: A Review,” ISRN Dentistry, vol. 2013, pp. 1–5, 2013. View at Publisher · View at Google Scholar
  71. C. A. Anderson, M. E. J. Curzon, C. Van Loveren, C. Tatsi, and M. S. Duggal, “Sucrose and dental caries: A review of the evidence,” Obesity Reviews, vol. 10, no. 1, pp. 41–54, 2009. View at Publisher · View at Google Scholar · View at Scopus
  72. M. Gil-Campos, M. San José González, and J. Díaz Martín, “Use of sugars and sweeteners in children's diets. Recommendations of the Nutrition Committee of the Spanish Association of Paediatrics,” Anales de Pediatría (English Edition), vol. 83, no. 5, pp. 353.e1–353.e7, 2015. View at Publisher · View at Google Scholar
  73. L. Angarita Davila, J. López Miranda, and D. Aparicio Camargo, “Índice glicémico, carga glicémica e insulina posprandial a dos fórmulas isoglucídicas con distintos edulcorantes y fibra en adultos sanos y diabéticos tipo 2,” Nutrición Hospitalaria, vol. 34, no. 3, pp. 532–539, 2017. View at Publisher · View at Google Scholar
  74. O. Ojo and J. Brooke, “Evaluation of the role of enteral nutrition in managing patients with diabetes: a systematic review,” Nutrients, vol. 6, no. 11, pp. 5142–5152, 2014. View at Publisher · View at Google Scholar · View at Scopus
  75. A. Sanz-Paris, D. Boj-Carceller, B. Lardies-Sanchez, L. Perez-Fernandez, and A. J. Cruz-Jentoft, “Health-care costs, glycemic control and nutritional status in malnourished older diabetics treated with a hypercaloric diabetes-specific enteral nutritional formula,” Nutrients, vol. 8, no. 3, article no. 153, 2016. View at Publisher · View at Google Scholar · View at Scopus