Atrial Structural Remodeling Gene Variants in Patients with Atrial Fibrillation
Table 5
Genes associated with cardiac diseases.
Gene
Protein
Cardiac diseases classification
Protein localisation
LQTS
SQTS
BrS
SIDS
CDM
CHD
AF
ABCC8
Sulfonylurea receptor 1
X
–
–
–
X
X
X
Sarcolemma
AKAP9
A-kinase anchor protein 9
X
–
X
X
X
–
–
Centrosome
DSG2
Desmoglein 2
–
–
X
–
X
–
X
Desmosome
DSP
Desmoplakin
X
–
X
X
X
–
X
Desmosome
FHOD3
FH1/FH2 domain-containing protein 3
–
–
–
–
X
–
–
Z-disk
JPH2
Junctophilin 2
–
–
X
–
X
–
X
Sarcoplasmic reticulum
MMP9
Matrix metalloproteinase-9
X
–
–
–
X
X
X
Extracellular matrix
MYOZ1
Myozenin-1
–
–
–
–
X
–
X
Z-disk
TMEM43
Transmembrane protein 43
–
–
X
–
X
–
–
Transmembrane
The presence of an (X) indicates involvement of the gene in each specific cardiac disease classification. The localisation of the protein encoded by each disease gene is also described. Abbreviations: BrS = Brugada syndrome; CDM = cardiomyopathies; CHD = congenital heart diseases; LQTS = long QT syndrome; SIDS = sudden infant death syndrome; SQTS = short QT syndrome.
