Costus afer Protects Cardio-, Hepato-, and Reno-Antioxidant Status in Streptozotocin-Intoxicated Wistar Rats
Table 2
Effect of C. afer on biochemical parameters in streptozotocin-diabetic rats.
Biochemical Parameters
Normal Control
Diabetic Control
DHE 250 mg/Kg
DHE 500 mg/Kg
DHE 1000 mg/Kg
Metformin
ALT (UI/L)
76.92±6.68
89.86±27.08
76.46±5.13
75.54±5.26
74.92±4.32
74.15±4.68
AST (UI/L)
15.86±1.29
19.89±2.21
15.73±0.91
15.43±0.52
12.36±2.66
12.48±1.73
ALP (UI/L)
7.90±1.05
15.15±1.23
8.82±3.29
7.35±1.13
10.11±1.59
10.84±2.19
LDH (UI/L)
160±20.19
212±31.14
199±16.00
191±69.41
218±29.76
175±48.73
CRE (mg/dL)
1.01±0.14
1.64±0.04
1.23±0.15
0.92±0.16
0.83±0.04
0.80 ±0.12
UREA (mg/dL)
47.59±3.02
70.97±17.92
64.85±9.98
43.75±13.87
47.94±6.12
25.85±2.98
BIL (mg/dL)
2.33±0.61
2.65±0.14
1.98±0.26
2.57±0.08
2.68±0.13
2.77±0.11
Total Protein (mg/dL)
67.56±6.95
70.55±4.54
67.40±2.69
63.75±3.17
67.33±2.19
53.41±13.67
AST (Aspartate transaminase); ALT (Alanine transaminase); ALP (Alkaline phosphatase); LDH (lactate dehydrogenase); CRE (Creatinine); BIL (bilirubin total). The data represents the Mean ± SD for each group of rats. n = 6 (number of animals per group); p<0.05 = significant difference.
