|
| Modifier | Pathway | Effect |
|
Fer1HCH/Fer2LCH
(Co-expression) | Iron storage | Suppressor of
reduced life span [66], ERG, and photoreceptor neurodegeneration [45] |
|
| Fer3HCH (OE) | Iron storage and oxidative stress protection | Suppressor of
reduced life span [66] ERG, and photoreceptor neurodegeneration [45] |
|
Irp-1A (RNAi)
Irp-1B (RNAi)
Irp-1B (LOF) | Iron sensor | Suppressor of
mild rough eye and impaired motor performance [82] |
|
| mfrn (RNAi) | Mitochondrial iron importer | Suppressor of
reduced aconitase activity and IRP-1A and ferritin levels, impaired motor performance, and increased brain vacuolization [66] |
| mfrn (OE) | Enhancer of
locomotor defects and brain vacuolization
[66] |
|
| Mvl (RNAi) | Iron absorption | Suppressor of
mild rough eye and impaired motor performance [82] |
|
Tsf1 (LOF)
Tsf3 (RNAi) | Serum iron binding transport proteins | Suppressor of
mild rough eye and impaired motor performance [82] |
|
dZip42C.1 (RNAi)
dZip42C.2 (RNAi)
dZip88E (RNAi) | Zinc importer | Suppressor of
mild rough eye and impaired motor performance [82] |
|
| dZnT35C (RNAi) | Zinc transporter to vesicles | Suppressor of
mild rough eye and impaired motor performance [82] |
|
| dZnT41F (RNAi) | Zinc homeostasis | Suppressor of
mild rough eye and impaired motor performance [82] |
|
| dZnT63C (RNAi) | Zinc exporter | Suppressor of
mild rough eye and impaired motor performance [82] |
|
| foi (LOF) | Zinc importer | Suppressor of
impaired motor performance [82] |
|
| Atox1 (RNAi) | Copper chaperone donor | Suppressor of
mild rough eye and impaired motor performance [82] |
|
| dCutC (RNAi) | Copper uptake and storage | Suppressor of
mild rough eye and impaired motor performance [82] |
|
| MTF-1 (OE) | Metal responsive Transcription Factor | Suppressor of
impaired motor performance [82] |
| MTF-1 (LOF) | Enhancer of
impaired motor performance [82] |
|
| MtnA (RNAi) | Heavy metal detoxification | Suppressor of
mild rough eye and impaired motor performance [82] |
|
MtnB (RNAi)
MtnC (RNAi) | Heavy metal detoxification | Suppressor of
mild rough eye [82] |
|
| Tsc1 (RNAi) | TORC1 pathway | Enhancer of
reduced survival [81] |
|
| S6K (DN) | TORC1 pathway | Suppressor of
impaired motor performance [81] |
| S6K (CA) | Enhancer of
reduced survival [81] |
|
| eIF-4E (LOF) | TORC1 pathway | Suppressor of
impaired motor performance [81] |
|
| Lrrk (RNAi) | TORC1 pathway | Suppressor of
impaired motor performance [81] |
|
Cat (OE)
mCat (OE)
mTPx (OE) | Antioxidant (hydrogen peroxide scavengers) | Suppressor of
reduced lifespan when overexpressed in the PNS [41] |
|
| dGLaz (OE) | Antioxidant defense | Suppressor of
reduced life span, impaired motor performance, aconitase inactivation, and lipid peroxidation [83] |
|
| Pdk1 (RNAi) | Embryonic development (insulin receptor transduction pathway and apoptotic pathway) | Suppressor of
photoreceptor neurodegeneration [45] |
|
| Mef2 (RNAi) | Muscle differentiation | Suppressor of
photoreceptor neurodegeneration [45] |
|
| lace (RNAi) | Sphingosine biosynthesis pathway | Suppressor of
photoreceptor neurodegeneration [45] |
|
