Drosophila melanogaster Models of Friedreich’s Ataxia

Table 4

Compounds that showed beneficial effects in Drosophila models of FRDA.

Compound	Mechanism of action	Improved phenotype
Idebenone	Antioxidant	Motor performance and; lifespan in adults [42, 49]
Methylene blue	Electron carrier	Adult heart function [42]
Toluidine blue	Electron carrier	Adult heart function [42]
Deferiprone	Iron chelator	Motor performance and; lifespan in adults [49]
Deferoxamine	Iron chelator	Pupa development [88]
LPS 01-03-L-F03	Possible iron chelator	Pupa development [88]
LPS 02-25-L-E10	Possible iron chelator	Pupa development [88]
LPS 02-13-L-E04	Possible iron chelator	Pupa development [88]
LPS 01-04-L-G10	n.d.	Pupa development [88]; Adult heart function [88]
LPS 02-14-L-B11	n.d.	Pupa development [88]
Rapamycin	TORC1 inhibitor	Motor performance and; oxidative stress in adults [81]
Myriocin	Serine palmitoyltransferase inhibitor	Photoreceptor function [45]

n.d.: not described.