BioMed Research International

Research Article

Clinical, Histological, and Immunohistochemical Findings in Inclusion Body Myositis

Table 4

General data, histological, immunohistochemical and deposits of amyloid (Congo-red) of muscle biopsies in 18 cases with sIBM and controls.
CaseBiopsy dateHistologic diagnosesFiber size variationNecrosisMacrophagyRVAAFCCConnective tissue increaseNCInflammatory infiltratesIAPRMitochondrial changesCongo-red
EMyPMyEMyPMyPVCOX−SDH+RRF
1                   
 a02/11UM+APAPP+++PAA+PPAP
 b02/13IBM++PAPPP+++++PAA+APAP
209/12IBM++PAPAP++++++PPA++AAAP
304/12IBM++PPPPP++++PPA++PPPP
4                   
 a09/11UM+PAAAP++++PPA++PPAP
 b11/13IBM++PAPAP++++PAA+AAAP
5                   
 a12/10IBM+PPPAP++++PPA+PPAP
 b06/14IBM+++AAPAP+++++++PAA++PPAP
602/14IBM++AAPAP++++PAA++AAAP
7                   
 a10/13DIST+++AAAAP++++++++PAA+++AAAU
 b03/14IBM+++PPPPP++++++PAA++PAAP
802/14IBM++AAPAP++++PAA++AAAP
904/10IBM++PAPPP+A+PPP+AAAP
10                   
 a07/10IBM+AAPAP+++PPP+AAAU
 b09/13IBM+PAPAP++++PPA++PAAP
11                   
 a05/04IBM+PPPAP+++PPP+AAAU
 b01/16IBM+PPPAPA++PAA+PPPP
12                   
 a05/12UM+PAAPAAA+PAA+AAAU
 b07/12IBM+PPPPPA+++PPA+PAAP
1310/14IBM++PPPPP++++++PAA+PAAP
1405/14IBM+PPPPP+A++PAA++AAAP
1502/15IBM+PPPPP++++PPA+PAAP
1610/14IBM+PPPAP++++PAA+PPPP
1710/14IBM+AAPPP+++++PAA+APAP
1811/14IBM+PPPPP+++PAA++PPPP
Controls
1905/14NLAAAAAA++AAAAAAAAA
2003/14DM+AAAPP+++PPP++AAAA
2102/14DM++AAAPP+++++PPP+AAAA
2208/13PM+PAAAPAA+PPA++AAAA
2308/13PM+PAAAP+++PPA+++AAAA
IBM = inclusion body myositis. UM = unspecific myopathic changes. DIST = dystrophic pattern. A = absent. P = present. U = unrealized. EMy = endomysial. PMy = perimysial. PV = perivascular. IAPR = increased acid phosphatase reaction. AAF = angulated atrophic fibers. CC = cytoarchitecture changes. NC = nuclear centralization. RV = rimmed vacuoles. Biopsy date (month/year). +: mild. ++: moderate. +++: severe.