Clinical, Histological, and Immunohistochemical Findings in Inclusion Body Myositis

Table 5

Immunohistochemical findings of muscle biopsies in 18 cases with sIBM and controls.

Case	CD68	CD4	CD8	MHC-I	LC3B	syn	TDP-43	p62
1
a	++	+	+	+++	P	P	P	P
b	++	+	+	+	A	P	P	P
2	+++	+	++	+++	P	P	P	P
3	+++	+	+	++	P	P	P	P
4
a	++	+	+	+++	P	P	P	P
b	+++	+	++	+++	P	P	P	P
5
a	++	+	+	++	A	P	P	P
b	++	++	++	++	P	P	P	P
6	+++	++	+	++	A	P	P	P
7
a	+	+	+	++	U	U	U	U
b	++	+	++	++	P	P	P	P
8	+++	+	+	+++	P	P	P	P
9	++	+	+	++	A	P	P	P
10
a	U	U	U	U	U	P	U	P
b	++	+	++	++	P	P	P	P
11
a	U	U	U	U	U	U	U	U
b	+	+	+	++	P	P	P	P
12
a	U	U	U	U	U	U	U	U
b	++	+	+	+++	A	P	P	P
13	++	+	+	++	P	A	P	P
14	++	+	+	++	A	P	P	P
15	++	+	+++	+++	P	P	P	P
16	++	+	+	+++	P	P	P	P
17	++	+	+	+++	A	A	P	P
18	++	++	++	+++	A	P	P	P
Controls
19	++	A	A	A	A	A	A	A
20	A	+	+	++	A	A	A	A
21	++	+	+	+	A	A	A	A
22	+	+	+	+++	A	A	A	A
23	++	+	++	+++	A	A	A	A

A = absent. P = present. U = undone. LC3B = microtubule-associated protein light chain 3. Syn = alpha-synuclein. TDP-43 = transactive response DNA binding protein 43 kDa. P62/SQSTM1 protein = p62/sequestosome 1. MHC-I = main complex histocompatibility type 1. CD4 and CD8 = lymphocytes markers. CD68 = macrophage marker. +: mild. ++: moderate. +++: severe.