Association between Polymorphisms of Antioxidant Gene (MnSOD, CAT, and GPx1) and Risk of Coronary Artery Disease
Table 1
Demographic and clinical characteristics of the study population.
Variablesa
Cases, n (%) N=447
Controls, n (%) N=210
p-valueb
Male
329(73.6)
130(61.9)
0.002
Age (mean ± SD), years
64.8±12.2
58.1±12.6
<0.001
BMI (mean ± SD), kg/m2
25.3±4.03
25.5±3.8
0.546
Stenosis 1 / 2 / 3
159/129/159
Ethnic group
0.591
Taiwanese
336(76.9)
165(79.7)
Mainland Chinese
59(13.5)
27(13.0)
Otherc
42(9.6)
15(7.3)
Occupation
0.390
White-collar
73(17.1)
27(13.0)
Blue-collar
141(32.9)
69(33.2)
Otherd
214(50.0)
112(53.8)
Family CAD history
104(24.9)
44(23.0)
0.508
History of hypertension
229(51.2)
84(40.0)
0.007
History of DM
173(38.7)
24(11.4)
<0.001
Cigarette smoking
<0.001
None
194(43.5)
129(61.4)
Current smokers
195(43.7)
59(28.1)
Ex-Smokers
57(12.8)
22(10.5)
Alcohol drinking
0.853
None
344(77.5)
157(75.8)
Current drinkers
97(21.8)
48(23.2)
Ex-drinkers
3(0.7)
2(1.0)
Creatinine (mean ± SD), mg/dl
2.0±2.6
1.4±2.0
0.005
Uric acid (mean ± SD), mg/dl
8.0±2.5
7.3±2.1
<0.001
HDL-C (mean ± SD), mg/dl
34.7±12.2
37.6±15.0
0.009
LDL-C (mean ± SD), mg/dl
175.4±54.0
157.9±41.7
<0.001
Cholesterol (mean ± SD), mg/dl
244.2±61.2
219.2±45.2
<0.001
Non-HDL-C (mean ± SD), mg/dl
211.8±59.3
185.9±43.1
<0.001
TRL-C (mean ± SD), mg/dl
35.4±38.3
27.5±28.8
0.006
Triglyceride [median (IQR)], mg/dl
153 (100-239)
112.0 (76-184)
<0.001
TRL-C, triglyceride-rich lipoprotein cholesterol; IQR, interquartile range. a: numbers not equal to total number were due to missing data. b: Student’s t-test, Wilcoxon rank-sum test or Chi-squared test. c: including Hakka and aborigines. d: including retiree and housekeeper.
