Association between Polymorphisms of Antioxidant Gene (MnSOD, CAT, and GPx1) and Risk of Coronary Artery Disease

Table 2

Association between MnSOD, CAT, and GPx1 genotypes and risk of coronary artery disease.

Genotype	Cases, n (%) N=447	Controls, n (%) N=210	OR(95% CI)^a	P-value
MnSOD Val-9Ala
Val/Val	352(78.7)	181(86.2)	1.00
Val/Ala	83(18.6)	27(12.9)	1.82(1.10-2.99)	0.019
Ala/Ala	12(2.7)	2(0.9)	2.40(0.51-11.3)	0.269
P for trend			0.012
Val/Val	352(78.8)	181(86.2)	1.00
Val/Ala+Ala/Ala	95(21.2)	29(13.8)	1.86(1.15-3.01)	0.011
CAT C-262T
C/C	403(90.2)	197(93.8)	1.00
C/T	42(9.4)	13(6.2)	1.43(0.73-2.82)	0.299
T/T	2(0.5)	0(0.0)	—	0.982
C/C	403(90.2)	197(93.8)	1.00
C/T+T/T	44(9.8)	13(6.2)	1.51(0.77-2.95)	0.233
GPx1 Pro198Leu
Pro/Pro	406(90.8)	191(90.9)	1.00
Pro/Leu	41(9.2)	19(9.1)	1.08(0.58-1.99)	0.817

a: adjusted for age, sex, cigarette smoking, and alcohol drinking.